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The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD.
Ghosh S, Sharma R, Bammidi S, Koontz V, Nemani M, Yazdankhah M, Kedziora KM, Stolz DB, Wallace CT, Yu-Wei C, Franks J, Bose D, Shang P, Ambrosino HM, Dutton JR, Geng Z, Montford J, Ryu J, Rajasundaram D, Hose S, Sahel JA, Puertollano R, Finkel T, Zigler JS Jr, Sergeev Y, Watkins SC, Goetzman ES, Ferrington DA, Flores-Bellver M, Kaarniranta K, Sodhi A, Bharti K, Handa JT, Sinha D. Ghosh S, et al. Among authors: zigler js jr. Nat Commun. 2024 Jul 21;15(1):6150. doi: 10.1038/s41467-024-50500-z. Nat Commun. 2024. PMID: 39034314 Free PMC article.
Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy.
Liu H, Ghosh S, Vaidya T, Bammidi S, Huang C, Shang P, Nair AP, Chowdhury O, Stepicheva NA, Strizhakova A, Hose S, Mitrousis N, Gadde SG, Mb T, Strassburger P, Widmer G, Lad EM, Fort PE, Sahel JA, Zigler JS Jr, Sethu S, Westenskow PD, Proia AD, Sodhi A, Ghosh A, Feenstra D, Sinha D. Liu H, et al. Among authors: zigler js jr. JCI Insight. 2023 Jun 22;8(12):e168945. doi: 10.1172/jci.insight.168945. JCI Insight. 2023. PMID: 37345657 Free PMC article.
Microglia-Neutrophil Interactions Drive Dry AMD-like Pathology in a Mouse Model.
Boyce M, Xin Y, Chowdhury O, Shang P, Liu H, Koontz V, Strizhakova A, Nemani M, Hose S, Zigler JS Jr, Campbell M, Sinha D, Handa JT, Kaarniranta K, Qian J, Ghosh S. Boyce M, et al. Among authors: zigler js jr. Cells. 2022 Nov 9;11(22):3535. doi: 10.3390/cells11223535. Cells. 2022. PMID: 36428965 Free PMC article.
Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.
Liu H, Stepicheva NA, Ghosh S, Shang P, Chowdhury O, Daley RA, Yazdankhah M, Gupta U, Hose SL, Valapala M, Fitting CS, Strizhakova A, Shan Y, Feenstra D, Sahel JA, Jayagopal A, Handa JT, Zigler JS Jr, Fort PE, Sodhi A, Sinha D. Liu H, et al. Among authors: zigler js jr. Nat Commun. 2022 Oct 13;13(1):6045. doi: 10.1038/s41467-022-33773-0. Nat Commun. 2022. PMID: 36229454 Free PMC article.
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.
Gupta U, Ghosh S, Wallace CT, Shang P, Xin Y, Nair AP, Yazdankhah M, Strizhakova A, Ross MA, Liu H, Hose S, Stepicheva NA, Chowdhury O, Nemani M, Maddipatla V, Grebe R, Das M, Lathrop KL, Sahel JA, Zigler JS Jr, Qian J, Ghosh A, Sergeev Y, Handa JT, St Croix CM, Sinha D. Gupta U, et al. Among authors: zigler js jr. Autophagy. 2023 Jan;19(1):92-111. doi: 10.1080/15548627.2022.2062887. Epub 2022 Apr 26. Autophagy. 2023. PMID: 35473441 Free PMC article.
βA1-crystallin regulates glucose metabolism and mitochondrial function in mouse retinal astrocytes by modulating PTP1B activity.
Ghosh S, Liu H, Yazdankhah M, Stepicheva N, Shang P, Vaidya T, Hose S, Gupta U, Calderon MJ, Hu MW, Nair AP, Weiss J, Fitting CS, Bhutto IA, Gadde SGK, Naik NK, Jaydev C, Lutty GA, Handa JT, Jayagopal A, Qian J, Sahel JA, Rajasundaram D, Sergeev Y, Zigler JS Jr, Sethu S, Watkins S, Ghosh A, Sinha D. Ghosh S, et al. Among authors: zigler js jr. Commun Biol. 2021 Feb 24;4(1):248. doi: 10.1038/s42003-021-01763-5. Commun Biol. 2021. PMID: 33627831 Free PMC article.
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Yazdankhah M, Ghosh S, Shang P, Stepicheva N, Hose S, Liu H, Chamling X, Tian S, Sullivan MLG, Calderon MJ, Fitting CS, Weiss J, Jayagopal A, Handa JT, Sahel JA, Zigler JS Jr, Kinchington PR, Zack DJ, Sinha D. Yazdankhah M, et al. Among authors: zigler js jr. Autophagy. 2021 Oct;17(10):3140-3159. doi: 10.1080/15548627.2020.1871204. Epub 2021 Jan 19. Autophagy. 2021. PMID: 33404293 Free PMC article.
168 results