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Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling.
Yardeni T, Olali AZ, Chen HW, Wang L, Halton JA, Zenab A, Morrow R, Butic A, Murdock DG, Waymire KG, MacGregor GR, Boursi B, Beier UH, Hancock WW, Wallace DC. Yardeni T, et al. Among authors: beier uh. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2417252121. doi: 10.1073/pnas.2417252121. Epub 2025 Jan 3. Proc Natl Acad Sci U S A. 2025. PMID: 39752523 Free article.
Differential Effects of HDAC6 Inhibition Versus Knockout During Hepatic Ischemia-Reperfusion Injury Highlight Importance of HDAC6 C-terminal Zinc-finger Ubiquitin-binding Domain.
Concors SJ, Hernandez PT, O'Brien C, DePaolo J, Murken DR, Aufhauser DD, Wang Z, Xiong Y, Krumeich L, Ge G, Beier UH, Bhatti TR, Kozikowski AP, Avelar LAA, Kurz T, Hancock WW, Levine MH. Concors SJ, et al. Among authors: beier uh. Transplantation. 2024 Oct 1;108(10):2084-2092. doi: 10.1097/TP.0000000000005042. Epub 2024 Sep 24. Transplantation. 2024. PMID: 38685198
Thermogenic T cells: a cell therapy for obesity?
Beier UH, Baker DJ, Baur JA. Beier UH, et al. Am J Physiol Cell Physiol. 2022 Jun 1;322(6):C1085-C1094. doi: 10.1152/ajpcell.00034.2022. Epub 2022 Apr 27. Am J Physiol Cell Physiol. 2022. PMID: 35476503 Free PMC article. Review.
Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo.
Siska PJ, Jiao J, Matos C, Singer K, Berger RS, Dettmer K, Oefner PJ, Cully MD, Wang Z, QuinnIII WJ, Oliff KN, Wilkins BJ, Christensen LM, Wang L, Hancock WW, Baur JA, Levine MH, Ugele I, Mayr R, Renner K, Zhou L, Kreutz M, Beier UH. Siska PJ, et al. Among authors: beier uh. EBioMedicine. 2021 Dec;74:103734. doi: 10.1016/j.ebiom.2021.103734. Epub 2021 Dec 4. EBioMedicine. 2021. PMID: 34875457 Free PMC article.
Obesity-related IL-18 Impairs T-Regulatory Cell Function and Promotes Lung Ischemia-Reperfusion Injury.
Akimova T, Zhang T, Christensen LM, Wang Z, Han R, Negorev D, Samanta A, Sasson IE, Gaddapara T, Jiao J, Wang L, Bhatti TR, Levine MH, Diamond JM, Beier UH, Simmons RA, Cantu E, Wilkes DS, Lederer DJ, Anderson M, Christie JD, Hancock WW. Akimova T, et al. Among authors: beier uh. Am J Respir Crit Care Med. 2021 Nov 1;204(9):1060-1074. doi: 10.1164/rccm.202012-4306OC. Am J Respir Crit Care Med. 2021. PMID: 34346860 Free PMC article.
HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury.
Aufhauser DD Jr, Hernandez P, Concors SJ, O'Brien C, Wang Z, Murken DR, Samanta A, Beier UH, Krumeich L, Bhatti TR, Wang Y, Ge G, Wang L, Cheraghlou S, Wagner FF, Holson EB, Kalin JH, Cole PA, Hancock WW, Levine MH. Aufhauser DD Jr, et al. Among authors: beier uh. Sci Rep. 2021 Apr 27;11(1):9018. doi: 10.1038/s41598-021-88242-3. Sci Rep. 2021. PMID: 33907245 Free PMC article.
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