Newell DR - Search Results

1

Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.

Hollick JJ, Rigoreau LJ, Cano-Soumillac C, Cockcroft X, Curtin NJ, Frigerio M, Golding BT, Guiard S, Hardcastle IR, Hickson I, Hummersone MG, Menear KA, Martin NM, Matthews I, Newell DR, Ord R, Richardson CJ, Smith GC, Griffin RJ. Hollick JJ, et al. Among authors: newell dr. J Med Chem. 2007 Apr 19;50(8):1958-72. doi: 10.1021/jm061121y. Epub 2007 Mar 20. J Med Chem. 2007. PMID: 17371003

2

In vivo and ex vivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review.

Newell DR, Maxwell RJ, Golding BT. Newell DR, et al. NMR Biomed. 1992 Sep-Oct;5(5):273-8. doi: 10.1002/nbm.1940050514. NMR Biomed. 1992. PMID: 1449968 Review.

3

Modulation of dipyridamole action by alpha 1 acid glycoprotein. Reduced potentiation of quinazoline antifolate (CB3717) cytotoxicity by dipyridamole.

Curtin NJ, Newell DR, Harris AL. Curtin NJ, et al. Among authors: newell dr. Biochem Pharmacol. 1989 Oct 1;38(19):3281-8. doi: 10.1016/0006-2952(89)90626-6. Biochem Pharmacol. 1989. PMID: 2818627

4

Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP).

Griffin RJ, Pemberton LC, Rhodes D, Bleasdale C, Bowman K, Calvert AH, Curtin NJ, Durkacz BW, Newell DR, Porteous JK, et al. Griffin RJ, et al. Among authors: newell dr. Anticancer Drug Des. 1995 Sep;10(6):507-14. Anticancer Drug Des. 1995. PMID: 7575991 No abstract available.

5

The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy.

Griffin RJ, Curtin NJ, Newell DR, Golding BT, Durkacz BW, Calvert AH. Griffin RJ, et al. Among authors: newell dr. Biochimie. 1995;77(6):408-22. doi: 10.1016/0300-9084(96)88154-5. Biochimie. 1995. PMID: 7578423 Review.

6

Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).

Arris CE, Bleasdale C, Calvert AH, Curtin NJ, Dalby C, Golding BT, Griffin RJ, Lunn JM, Major GN, Newell DR. Arris CE, et al. Among authors: newell dr. Anticancer Drug Des. 1994 Oct;9(5):401-8. Anticancer Drug Des. 1994. PMID: 7945724 No abstract available.

7

Dipyridamole potentiates antipurine antifolate activity in the presence of hypoxanthine in tumor cells but not in normal tissues in vitro.

Marshman E, Newell DR, Calvert AH, Dickinson AM, Patel HR, Campbell FC, Curtin NJ. Marshman E, et al. Among authors: newell dr. Clin Cancer Res. 1998 Nov;4(11):2895-902. Clin Cancer Res. 1998. PMID: 9829758

8

Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

Griffin RJ, Srinivasan S, Bowman K, Calvert AH, Curtin NJ, Newell DR, Pemberton LC, Golding BT. Griffin RJ, et al. Among authors: newell dr. J Med Chem. 1998 Dec 17;41(26):5247-56. doi: 10.1021/jm980273t. J Med Chem. 1998. PMID: 9857092

9

Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.

Curtin NJ, Bowman KJ, Turner RN, Huang B, Loughlin PJ, Calvert AH, Golding BT, Griffin RJ, Newell DR. Curtin NJ, et al. Among authors: newell dr. Br J Cancer. 1999 Aug;80(11):1738-46. doi: 10.1038/sj.bjc.6690591. Br J Cancer. 1999. PMID: 10468290 Free PMC article.

10

Prevention of thymidine and hypoxanthine rescue from MTA (LY231514) growth inhibition by dipyridamole in human lung cancer cell lines.

Smith PG, Marshman E, Calvert AH, Newell DR, Curtin NJ. Smith PG, et al. Among authors: newell dr. Semin Oncol. 1999 Apr;26(2 Suppl 6):63-7. Semin Oncol. 1999. PMID: 10598557

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