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Page 1
NF-κB is a critical mediator of BRCA1-induced chemoresistance.
Harte MT, Gorski JJ, Savage KI, Purcell JW, Barros EM, Burn PM, McFarlane C, Mullan PB, Kennedy RD, Perkins ND, Harkin DP. Harte MT, et al. Among authors: purcell jw. Oncogene. 2014 Feb 6;33(6):713-723. doi: 10.1038/onc.2013.10. Epub 2013 Feb 25. Oncogene. 2014. PMID: 23435429 Free PMC article.
STAT1: a modulator of chemotherapy-induced apoptosis.
Thomas M, Finnegan CE, Rogers KM, Purcell JW, Trimble A, Johnston PG, Boland MP. Thomas M, et al. Among authors: purcell jw. Cancer Res. 2004 Nov 15;64(22):8357-64. doi: 10.1158/0008-5472.CAN-04-1864. Cancer Res. 2004. PMID: 15548705
Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer.
Ray U, Jung DB, Jin L, Xiao Y, Dasari S, Sarkar Bhattacharya S, Thirusangu P, Staub JK, Roy D, Roy B, Weroha SJ, Hou X, Purcell JW, Bakkum-Gamez JN, Kaufmann SH, Kannan N, Mitra AK, Shridhar V. Ray U, et al. Among authors: purcell jw. Cancer Res. 2022 Mar 15;82(6):1038-1054. doi: 10.1158/0008-5472.CAN-21-0622. Cancer Res. 2022. PMID: 34654724 Free PMC article.
LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates.
Purcell JW, Tanlimco SG, Hickson J, Fox M, Sho M, Durkin L, Uziel T, Powers R, Foster K, McGonigal T, Kumar S, Samayoa J, Zhang D, Palma JP, Mishra S, Hollenbaugh D, Gish K, Morgan-Lappe SE, Hsi ED, Chao DT. Purcell JW, et al. Cancer Res. 2018 Jul 15;78(14):4059-4072. doi: 10.1158/0008-5472.CAN-18-0327. Epub 2018 May 15. Cancer Res. 2018. PMID: 29764866
First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors.
Demetri GD, Luke JJ, Hollebecque A, Powderly JD 2nd, Spira AI, Subbiah V, Naumovski L, Chen C, Fang H, Lai DW, Yue H, Polepally AR, Purcell JW, Robinson R, Sharma P, Allison JP, Tolcher A, Villalobos VM. Demetri GD, et al. Among authors: purcell jw. Clin Cancer Res. 2021 Jul 1;27(13):3556-3566. doi: 10.1158/1078-0432.CCR-20-4513. Epub 2021 Apr 5. Clin Cancer Res. 2021. PMID: 33820780 Clinical Trial.
Exploiting LRRC15 as a Novel Therapeutic Target in Cancer.
Ray U, Pathoulas CL, Thirusangu P, Purcell JW, Kannan N, Shridhar V. Ray U, et al. Among authors: purcell jw. Cancer Res. 2022 May 3;82(9):1675-1681. doi: 10.1158/0008-5472.CAN-21-3734. Cancer Res. 2022. PMID: 35260879 Free PMC article. Review.
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