Koehler AN - Search Results

1

A method for the covalent capture and screening of diverse small molecules in a microarray format.

Bradner JE, McPherson OM, Koehler AN. Bradner JE, et al. Among authors: koehler an. Nat Protoc. 2006;1(5):2344-52. doi: 10.1038/nprot.2006.282. Nat Protoc. 2006. PMID: 17406478

2

A robust small-molecule microarray platform for screening cell lysates.

Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. Bradner JE, et al. Among authors: koehler an. Chem Biol. 2006 May;13(5):493-504. doi: 10.1016/j.chembiol.2006.03.004. Chem Biol. 2006. PMID: 16720270

3

A pipeline for ligand discovery using small-molecule microarrays.

Duffner JL, Clemons PA, Koehler AN. Duffner JL, et al. Among authors: koehler an. Curr Opin Chem Biol. 2007 Feb;11(1):74-82. doi: 10.1016/j.cbpa.2006.11.031. Epub 2006 Dec 13. Curr Opin Chem Biol. 2007. PMID: 17169601 Review.

4

Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules.

Miao H, Tallarico JA, Hayakawa H, Münger K, Duffner JL, Koehler AN, Schreiber SL, Lewis TA. Miao H, et al. Among authors: koehler an. J Comb Chem. 2007 Mar-Apr;9(2):245-53. doi: 10.1021/cc060135m. J Comb Chem. 2007. PMID: 17348730

5

Detecting binding interactions using microarrays of natural product extracts.

Schmitz K, Haggarty SJ, McPherson OM, Clardy J, Koehler AN. Schmitz K, et al. Among authors: koehler an. J Am Chem Soc. 2007 Sep 19;129(37):11346-7. doi: 10.1021/ja073965s. Epub 2007 Aug 24. J Am Chem Soc. 2007. PMID: 17718493 No abstract available.

6

Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors.

Vegas AJ, Bradner JE, Tang W, McPherson OM, Greenberg EF, Koehler AN, Schreiber SL. Vegas AJ, et al. Among authors: koehler an. Angew Chem Int Ed Engl. 2007;46(42):7960-4. doi: 10.1002/anie.200703198. Angew Chem Int Ed Engl. 2007. PMID: 17868168 Free PMC article. No abstract available.

7

Small-molecule microarrays as tools in ligand discovery.

Vegas AJ, Fuller JH, Koehler AN. Vegas AJ, et al. Among authors: koehler an. Chem Soc Rev. 2008 Jul;37(7):1385-94. doi: 10.1039/b703568n. Epub 2008 May 20. Chem Soc Rev. 2008. PMID: 18568164 Free PMC article. Review.

8

A small molecule that binds Hedgehog and blocks its signaling in human cells.

Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Stanton BZ, et al. Among authors: koehler an. Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18. Nat Chem Biol. 2009. PMID: 19151731 Free PMC article.

9

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.

Clemons PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, Schreiber SL. Clemons PA, et al. Among authors: koehler an. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18787-92. doi: 10.1073/pnas.1012741107. Epub 2010 Oct 18. Proc Natl Acad Sci U S A. 2010. PMID: 20956335 Free PMC article.

10

A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.

Kemp MM, Wang Q, Fuller JH, West N, Martinez NM, Morse EM, Weïwer M, Schreiber SL, Bradner JE, Koehler AN. Kemp MM, et al. Among authors: koehler an. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4164-9. doi: 10.1016/j.bmcl.2011.05.098. Epub 2011 Jun 2. Bioorg Med Chem Lett. 2011. PMID: 21696956 Free PMC article.

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