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Page 1
Identification of selective neuropeptide Y2 peptide agonists.
DeCarr LB, Buckholz TM, Coish PD, Fathi Z, Fisk SE, Mays MR, O'Connor SJ, Lumb KJ. DeCarr LB, et al. Among authors: lumb kj. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. doi: 10.1016/j.bmcl.2006.10.007. Epub 2006 Oct 7. Bioorg Med Chem Lett. 2007. PMID: 17055726
A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents.
Ortiz AA, Milardo LF, DeCarr LB, Buckholz TM, Mays MR, Claus TH, Livingston JN, Mahle CD, Lumb KJ. Ortiz AA, et al. Among authors: lumb kj. J Pharmacol Exp Ther. 2007 Nov;323(2):692-700. doi: 10.1124/jpet.107.125211. Epub 2007 Aug 1. J Pharmacol Exp Ther. 2007. PMID: 17671099
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
Katz JD, Jewell JP, Guerin DJ, Lim J, Dinsmore CJ, Deshmukh SV, Pan BS, Marshall CG, Lu W, Altman MD, Dahlberg WK, Davis L, Falcone D, Gabarda AE, Hang G, Hatch H, Holmes R, Kunii K, Lumb KJ, Lutterbach B, Mathvink R, Nazef N, Patel SB, Qu X, Reilly JF, Rickert KW, Rosenstein C, Soisson SM, Spencer KB, Szewczak AA, Walker D, Wang W, Young J, Zeng Q. Katz JD, et al. Among authors: lumb kj. J Med Chem. 2011 Jun 23;54(12):4092-108. doi: 10.1021/jm200112k. Epub 2011 May 24. J Med Chem. 2011. PMID: 21608528
Identification of potent inhibitors of the sortilin-progranulin interaction.
Stachel SJ, Ginnetti AT, Johnson SA, Cramer P, Wang Y, Bukhtiyarova M, Krosky D, Stump C, Hurzy DM, Schlegel KA, Cooke AJ, Allen S, O'Donnell G, Ziebell M, Parthasarathy G, Getty KL, Ho T, Ou Y, Jovanovska A, Carroll SS, Pausch M, Lumb K, Mosser SD, Voleti B, Klein DJ, Soisson SM, Zerbinatti C, Coleman PJ. Stachel SJ, et al. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403. doi: 10.1016/j.bmcl.2020.127403. Epub 2020 Jul 15. Bioorg Med Chem Lett. 2020. PMID: 32738972
63 results