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Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.
Iguchi-Hashimoto M, Usui T, Yoshifuji H, Shimizu M, Kobayashi S, Ito Y, Murakami K, Shiomi A, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T. Iguchi-Hashimoto M, et al. Among authors: ito y. PLoS One. 2011;6(10):e27020. doi: 10.1371/journal.pone.0027020. Epub 2011 Oct 27. PLoS One. 2011. PMID: 22046434 Free PMC article.
Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.
Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T. Ito Y, et al. Among authors: ito h. Arthritis Rheum. 2009 Aug;60(8):2294-303. doi: 10.1002/art.24687. Arthritis Rheum. 2009. PMID: 19644886 Free article.
Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation.
Matsuo T, Hashimoto M, Sakaguchi S, Sakaguchi N, Ito Y, Hikida M, Tsuruyama T, Sakai K, Yokoi H, Shirakashi M, Tanaka M, Ito H, Yoshifuji H, Ohmura K, Fujii T, Mimori T. Matsuo T, et al. Among authors: ito h, ito y. J Immunol. 2019 Jun 1;202(11):3161-3172. doi: 10.4049/jimmunol.1801159. Epub 2019 Apr 24. J Immunol. 2019. PMID: 31019063
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.
Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S. Ito Y, et al. Among authors: ito h. Science. 2014 Oct 17;346(6207):363-8. doi: 10.1126/science.1259077. Science. 2014. PMID: 25324392 Free PMC article.
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S. Hirota K, et al. Among authors: ito h, ito y. Immunity. 2018 Jun 19;48(6):1220-1232.e5. doi: 10.1016/j.immuni.2018.04.009. Epub 2018 May 22. Immunity. 2018. PMID: 29802020 Free PMC article.
TREG-cell therapies for autoimmune rheumatic diseases.
Miyara M, Ito Y, Sakaguchi S. Miyara M, et al. Among authors: ito y. Nat Rev Rheumatol. 2014 Sep;10(9):543-51. doi: 10.1038/nrrheum.2014.105. Epub 2014 Jul 1. Nat Rev Rheumatol. 2014. PMID: 24980140 Review.
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