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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
Henne KR, Ason B, Howard M, Wang W, Sun J, Higbee J, Tang J, Matsuda KC, Xu R, Zhou L, Chan JC, King C, Piper DE, Ketchem RR, Michaels ML, Jackson SM, Retter MW. Henne KR, et al. Among authors: sun j. J Pharmacol Exp Ther. 2015 Apr;353(1):119-31. doi: 10.1124/jpet.114.221242. Epub 2015 Feb 4. J Pharmacol Exp Ther. 2015. PMID: 25653417
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes.
Hecht R, Li YS, Sun J, Belouski E, Hall M, Hager T, Yie J, Wang W, Winters D, Smith S, Spahr C, Tam LT, Shen Z, Stanislaus S, Chinookoswong N, Lau Y, Sickmier A, Michaels ML, Boone T, Véniant MM, Xu J. Hecht R, et al. Among authors: sun j. PLoS One. 2012;7(11):e49345. doi: 10.1371/journal.pone.0049345. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209571 Free PMC article.
Sovleplenib in patients with primary or secondary warm autoimmune haemolytic anaemia: results from phase 2 of a randomised, double-blind, placebo-controlled, phase 2/3 study.
Zhao X, Sun J, Zhang Z, Chen M, Gong T, He G, Li Y, Liu H, Li F, Li X, Zhou H, Wang X, Hong M, Lei L, Yin H, Luo X, Li Y, Fan S, Guo X, Shi MM, Su W, Zhang L, Han B, Zhang F. Zhao X, et al. Among authors: sun j. Lancet Haematol. 2025 Jan 9:S2352-3026(24)00344-2. doi: 10.1016/S2352-3026(24)00344-2. Online ahead of print. Lancet Haematol. 2025. PMID: 39799953
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