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Linkage of otosclerosis to a third locus (OTSC3) on human chromosome 6p21.3-22.3.
Chen W, Campbell CA, Green GE, Van Den Bogaert K, Komodikis C, Manolidis LS, Aconomou E, Kyamides Y, Christodoulou K, Faghel C, Giguére CM, Alford RL, Manolidis S, Van Camp G, Smith RJ. Chen W, et al. J Med Genet. 2002 Jul;39(7):473-7. doi: 10.1136/jmg.39.7.473. J Med Genet. 2002. PMID: 12114476 Free PMC article.
The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations.
Thys M, Schrauwen I, Vanderstraeten K, Janssens K, Dieltjens N, Van Den Bogaert K, Fransen E, Chen W, Ealy M, Claustres M, Cremers CR, Dhooge I, Declau F, Claes J, Van de Heyning P, Vincent R, Somers T, Offeciers E, Smith RJ, Van Camp G. Thys M, et al. Among authors: chen w. Hum Mol Genet. 2007 Sep 1;16(17):2021-30. doi: 10.1093/hmg/ddm150. Epub 2007 Jun 22. Hum Mol Genet. 2007. PMID: 17588962
A fifth locus for otosclerosis, OTSC5, maps to chromosome 3q22-24.
Van Den Bogaert K, De Leenheer EM, Chen W, Lee Y, Nürnberg P, Pennings RJ, Vanderstraeten K, Thys M, Cremers CW, Smith RJ, Van Camp G. Van Den Bogaert K, et al. Among authors: chen w. J Med Genet. 2004 Jun;41(6):450-3. doi: 10.1136/jmg.2004.018671. J Med Genet. 2004. PMID: 15173231 Free PMC article. No abstract available.
A seventh locus for otosclerosis, OTSC7, maps to chromosome 6q13-16.1.
Thys M, Van Den Bogaert K, Iliadou V, Vanderstraeten K, Dieltjens N, Schrauwen I, Chen W, Eleftheriades N, Grigoriadou M, Pauw RJ, Cremers CR, Smith RJ, Petersen MB, Van Camp G. Thys M, et al. Among authors: chen w. Eur J Hum Genet. 2007 Mar;15(3):362-8. doi: 10.1038/sj.ejhg.5201761. Epub 2007 Jan 10. Eur J Hum Genet. 2007. PMID: 17213839
Gene expression analysis of human otosclerotic stapedial footplates.
Ealy M, Chen W, Ryu GY, Yoon JG, Welling DB, Hansen M, Madan A, Smith RJ. Ealy M, et al. Among authors: chen w. Hear Res. 2008 Jun;240(1-2):80-6. doi: 10.1016/j.heares.2008.03.001. Epub 2008 Mar 15. Hear Res. 2008. PMID: 18430532 Free PMC article.
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