Lamb P - Search Results

1

The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1.

Pan J, Quintás-Cardama A, Manshouri T, Giles FJ, Lamb P, Tefferi A, Cortes J, Kantarjian H, Verstovsek S. Pan J, et al. Among authors: lamb p. Leukemia. 2007 Jul;21(7):1395-404. doi: 10.1038/sj.leu.2404714. Epub 2007 May 10. Leukemia. 2007. PMID: 17495975

2

EXEL-0862, a novel tyrosine kinase inhibitor, induces apoptosis in vitro and ex vivo in human mast cells expressing the KIT D816V mutation.

Pan J, Quintás-Cardama A, Kantarjian HM, Akin C, Manshouri T, Lamb P, Cortes JE, Tefferi A, Giles FJ, Verstovsek S. Pan J, et al. Among authors: lamb p. Blood. 2007 Jan 1;109(1):315-22. doi: 10.1182/blood-2006-04-013805. Epub 2006 Aug 15. Blood. 2007. PMID: 16912224 Free article.

3

Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes.

Tian SS, Tapley P, Sincich C, Stein RB, Rosen J, Lamb P. Tian SS, et al. Among authors: lamb p. Blood. 1996 Dec 15;88(12):4435-44. Blood. 1996. PMID: 8977235 Free article.

4

Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor.

Tian SS, Lamb P, Seidel HM, Stein RB, Rosen J. Tian SS, et al. Among authors: lamb p. Blood. 1994 Sep 15;84(6):1760-4. Blood. 1994. PMID: 7521688 Free article.

5

Rapid activation of proteins that interact with the interferon gamma activation site in response to multiple cytokines.

Lamb P, Kessler LV, Suto C, Levy DE, Seidel HM, Stein RB, Rosen J. Lamb P, et al. Blood. 1994 Apr 15;83(8):2063-71. Blood. 1994. PMID: 8161777 Free article.

6

EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation.

Trowe T, Boukouvala S, Calkins K, Cutler RE Jr, Fong R, Funke R, Gendreau SB, Kim YD, Miller N, Woolfrey JR, Vysotskaia V, Yang JP, Gerritsen ME, Matthews DJ, Lamb P, Heuer TS. Trowe T, et al. Among authors: lamb p. Clin Cancer Res. 2008 Apr 15;14(8):2465-75. doi: 10.1158/1078-0432.CCR-07-4367. Clin Cancer Res. 2008. PMID: 18413839

7

In vitro and in vivo activity of cabozantinib (XL184), an inhibitor of RET, MET, and VEGFR2, in a model of medullary thyroid cancer.

Bentzien F, Zuzow M, Heald N, Gibson A, Shi Y, Goon L, Yu P, Engst S, Zhang W, Huang D, Zhao L, Vysotskaia V, Chu F, Bautista R, Cancilla B, Lamb P, Joly AH, Yakes FM. Bentzien F, et al. Among authors: lamb p. Thyroid. 2013 Dec;23(12):1569-77. doi: 10.1089/thy.2013.0137. Epub 2013 Sep 17. Thyroid. 2013. PMID: 23705946 Free PMC article.

8

STAT protein complexes activated by interferon-gamma and gp130 signaling molecules differ in their sequence preferences and transcriptional induction properties.

Lamb P, Seidel HM, Haslam J, Milocco L, Kessler LV, Stein RB, Rosen J. Lamb P, et al. Nucleic Acids Res. 1995 Aug 25;23(16):3283-9. doi: 10.1093/nar/23.16.3283. Nucleic Acids Res. 1995. PMID: 7667105 Free PMC article.

9

Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity.

Seidel HM, Milocco LH, Lamb P, Darnell JE Jr, Stein RB, Rosen J. Seidel HM, et al. Among authors: lamb p. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3041-5. doi: 10.1073/pnas.92.7.3041. Proc Natl Acad Sci U S A. 1995. PMID: 7708771 Free PMC article.

10

Rapid activation of the interferon-gamma signal transduction pathway by inhibitors of tyrosine phosphatases.

Lamb P, Haslam J, Kessler L, Seidel HM, Stein RB, Rosen J. Lamb P, et al. J Interferon Res. 1994 Dec;14(6):365-73. doi: 10.1089/jir.1994.14.365. J Interferon Res. 1994. PMID: 7897256

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