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A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity.
Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, Nawrocki AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell RG, Lindemann D, Hartley A, Baker GR, Obici S, Deshaies Y, Ludgate M, Rossetti L, Scherer PE. Combs TP, et al. Among authors: scherer pe. Endocrinology. 2004 Jan;145(1):367-83. doi: 10.1210/en.2003-1068. Epub 2003 Oct 23. Endocrinology. 2004. PMID: 14576179
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.
Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE. Pajvani UB, et al. Among authors: scherer pe. J Biol Chem. 2004 Mar 26;279(13):12152-62. doi: 10.1074/jbc.M311113200. Epub 2003 Dec 29. J Biol Chem. 2004. PMID: 14699128 Free article.
Adiponectin acts in the brain to decrease body weight.
Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS. Qi Y, et al. Among authors: scherer pe. Nat Med. 2004 May;10(5):524-9. doi: 10.1038/nm1029. Epub 2004 Apr 11. Nat Med. 2004. PMID: 15077108
527 results