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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R. Kuhn A, et al. Among authors: ferrante rj. Hum Mol Genet. 2007 Aug 1;16(15):1845-61. doi: 10.1093/hmg/ddm133. Epub 2007 May 21. Hum Mol Genet. 2007. PMID: 17519223
Modulation of nucleosome dynamics in Huntington's disease.
Stack EC, Del Signore SJ, Luthi-Carter R, Soh BY, Goldstein DR, Matson S, Goodrich S, Markey AL, Cormier K, Hagerty SW, Smith K, Ryu H, Ferrante RJ. Stack EC, et al. Among authors: ferrante rj. Hum Mol Genet. 2007 May 15;16(10):1164-75. doi: 10.1093/hmg/ddm064. Epub 2007 Apr 2. Hum Mol Genet. 2007. PMID: 17403718 Free article.
MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition.
Taylor DM, Moser R, Régulier E, Breuillaud L, Dixon M, Beesen AA, Elliston L, Silva Santos Mde F, Kim J, Jones L, Goldstein DR, Ferrante RJ, Luthi-Carter R. Taylor DM, et al. Among authors: ferrante rj. J Neurosci. 2013 Feb 6;33(6):2313-25. doi: 10.1523/JNEUROSCI.4965-11.2013. J Neurosci. 2013. PMID: 23392662 Free PMC article.
Depletion of wild-type huntingtin in mouse models of neurologic diseases.
Zhang Y, Li M, Drozda M, Chen M, Ren S, Mejia Sanchez RO, Leavitt BR, Cattaneo E, Ferrante RJ, Hayden MR, Friedlander RM. Zhang Y, et al. Among authors: ferrante rj. J Neurochem. 2003 Oct;87(1):101-6. doi: 10.1046/j.1471-4159.2003.01980.x. J Neurochem. 2003. PMID: 12969257 Free article.
Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease.
Jenkins BG, Andreassen OA, Dedeoglu A, Leavitt B, Hayden M, Borchelt D, Ross CA, Ferrante RJ, Beal MF. Jenkins BG, et al. Among authors: ferrante rj. J Neurochem. 2005 Oct;95(2):553-62. doi: 10.1111/j.1471-4159.2005.03411.x. Epub 2005 Aug 31. J Neurochem. 2005. PMID: 16135087 Free article.
Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.
Stack EC, Dedeoglu A, Smith KM, Cormier K, Kubilus JK, Bogdanov M, Matson WR, Yang L, Jenkins BG, Luthi-Carter R, Kowall NW, Hersch SM, Beal MF, Ferrante RJ. Stack EC, et al. Among authors: ferrante rj. J Neurosci. 2007 Nov 21;27(47):12908-15. doi: 10.1523/JNEUROSCI.4318-07.2007. J Neurosci. 2007. PMID: 18032664 Free PMC article.
The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis.
Holbert S, Denghien I, Kiechle T, Rosenblatt A, Wellington C, Hayden MR, Margolis RL, Ross CA, Dausset J, Ferrante RJ, Néri C. Holbert S, et al. Among authors: ferrante rj. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1811-6. doi: 10.1073/pnas.98.4.1811. Epub 2001 Jan 30. Proc Natl Acad Sci U S A. 2001. PMID: 11172033 Free PMC article.
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.
Faideau M, Kim J, Cormier K, Gilmore R, Welch M, Auregan G, Dufour N, Guillermier M, Brouillet E, Hantraye P, Déglon N, Ferrante RJ, Bonvento G. Faideau M, et al. Among authors: ferrante rj. Hum Mol Genet. 2010 Aug 1;19(15):3053-67. doi: 10.1093/hmg/ddq212. Epub 2010 May 21. Hum Mol Genet. 2010. PMID: 20494921 Free PMC article.
171 results