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2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: discovery of CB2 receptor selective compounds.
Kai H, Morioka Y, Murashi T, Morita K, Shinonome S, Nakazato H, Kawamoto K, Hanasaki K, Takahashi F, Mihara S, Arai T, Abe K, Okabe H, Baba T, Yoshikawa T, Takenaka H. Kai H, et al. Among authors: yoshikawa t. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4030-4. doi: 10.1016/j.bmcl.2007.04.093. Epub 2007 Apr 30. Bioorg Med Chem Lett. 2007. PMID: 17521907
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.
Kai H, Morioka Y, Tomida M, Takahashi T, Hattori M, Hanasaki K, Koike K, Chiba H, Shinohara S, Kanemasa T, Iwamoto Y, Takahashi K, Yamaguchi Y, Baba T, Yoshikawa T, Takenaka H. Kai H, et al. Among authors: yoshikawa t. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3925-9. doi: 10.1016/j.bmcl.2007.04.099. Epub 2007 May 3. Bioorg Med Chem Lett. 2007. PMID: 17531479
Discovery of the Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{N-[(4S,5S)-(5-Methyl-2-oxooxazolidine-4-yl)carbonyl]-3-(thiazol-4-yl)-l-alanyl}-(2R)-2-methylpyrrolidine Trihydrate (Rovatirelin Hydrate).
Kobayashi N, Sato N, Fujimura Y, Kihara T, Sugita K, Takahashi K, Koike K, Sugawara T, Tada Y, Nakai H, Yoshikawa T. Kobayashi N, et al. Among authors: yoshikawa t. ACS Omega. 2018 Oct 31;3(10):13647-13666. doi: 10.1021/acsomega.8b01481. Epub 2018 Oct 19. ACS Omega. 2018. PMID: 30411045 Free PMC article.
4,776 results