Franklin RB - Search Results

1

The pharmacokinetics and disposition of MK-0524, a Prosglandin D2 Receptor 1 antagonist, in rats, dogs and monkeys.

Chang SW, Reddy V, Pereira T, Dean BJ, Xia YQ, Seto C, Franklin RB, Karanam BV. Chang SW, et al. Among authors: franklin rb. Xenobiotica. 2007 May;37(5):514-33. doi: 10.1080/00498250601175565. Xenobiotica. 2007. PMID: 17523054

2

The metabolic disposition of aprepitant, a substance P receptor antagonist, in rats and dogs.

Huskey SE, Dean BJ, Doss GA, Wang Z, Hop CE, Anari R, Finke PE, Robichaud AJ, Zhang M, Wang B, Strauss JR, Cunningham PK, Feeney WP, Franklin RB, Baillie TA, Chiu SH. Huskey SE, et al. Among authors: franklin rb. Drug Metab Dispos. 2004 Feb;32(2):246-58. doi: 10.1124/dmd.32.2.246. Drug Metab Dispos. 2004. PMID: 14744948

3

Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans.

Dean BJ, Chang S, Silva Elipe MV, Xia YQ, Braun M, Soli E, Zhao Y, Franklin RB, Karanam B. Dean BJ, et al. Among authors: franklin rb. Drug Metab Dispos. 2007 Feb;35(2):283-92. doi: 10.1124/dmd.106.011551. Epub 2006 Nov 28. Drug Metab Dispos. 2007. PMID: 17132765

4

Identification and metabolism of a novel dihydrohydroxy-S-glutathionyl conjugate of a peroxisome proliferator-activated receptor agonist, MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], in rats.

Reddy VB, Doss GA, Creighton M, Kochansky CJ, Vincent SH, Franklin RB, Karanam BV. Reddy VB, et al. Among authors: franklin rb. Drug Metab Dispos. 2004 Oct;32(10):1154-61. doi: 10.1124/dmd.104.000240. Epub 2004 Jun 30. Drug Metab Dispos. 2004. PMID: 15229171

5

Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.

Reddy VB, Karanam BV, Gruber WL, Wallace MA, Vincent SH, Franklin RB, Baillie TA. Reddy VB, et al. Among authors: franklin rb. Chem Res Toxicol. 2005 May;18(5):880-8. doi: 10.1021/tx0500373. Chem Res Toxicol. 2005. PMID: 15892582

6

Metabolism and disposition of gemfibrozil in Wistar and multidrug resistance-associated protein 2-deficient TR- rats.

Kim MS, Liu DQ, Strauss JR, Capodanno I, Yao Z, Fenyk-Melody JE, Franklin RB, Vincent SH. Kim MS, et al. Among authors: franklin rb. Xenobiotica. 2003 Oct;33(10):1027-42. doi: 10.1080/00498250310001602720. Xenobiotica. 2003. PMID: 14555339

7

Differences in the metabolism and pharmacokinetics of two structurally similar PPAR agonists in dogs: involvement of taurine conjugation.

Kim MS, Shen Z, Kochansky C, Lynn K, Wang S, Wang Z, Hora D, Brunner J, Franklin RB, Vincent SH. Kim MS, et al. Among authors: franklin rb. Xenobiotica. 2004 Jul;34(7):665-74. doi: 10.1080/00498250412331285445. Xenobiotica. 2004. PMID: 15672754

8

Identification of novel metabolites of pioglitazone in rat and dog.

Shen Z, Reed JR, Creighton M, Liu DQ, Tang YS, Hora DF, Feeney W, Szewczyk J, Bakhtiar R, Franklin RB, Vincent SH. Shen Z, et al. Among authors: franklin rb. Xenobiotica. 2003 May;33(5):499-509. doi: 10.1080/0049825031000085951. Xenobiotica. 2003. PMID: 12746106

9

Species and gender differences in the formation of an active metabolite of a substituted 2,4-thiazolidinedione insulin sensitizer.

Beconi M, Mao A, Creighton M, Hop CE, Chiu SH, Eydelloth R, Franklin R, Tang F, Yu N, Vincent S. Beconi M, et al. Xenobiotica. 2003 Jul;33(7):767-87. doi: 10.1080/0049825031000108333. Xenobiotica. 2003. PMID: 12893525

10

Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.

Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA. Kumar S, et al. Among authors: franklin rb. J Pharmacol Exp Ther. 2003 Mar;304(3):1161-71. doi: 10.1124/jpet.102.045096. J Pharmacol Exp Ther. 2003. PMID: 12604693

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