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Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2.
Scherer D, Kiesecker C, Kulzer M, Günth M, Scholz EP, Kathöfer S, Thomas D, Maurer M, Kreuzer J, Bauer A, Katus HA, Karle CA, Zitron E. Scherer D, et al. Among authors: thomas d. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):311-22. doi: 10.1007/s00210-007-0167-5. Epub 2007 May 30. Naunyn Schmiedebergs Arch Pharmacol. 2007. PMID: 17534603
Antiarrhythmic drug carvedilol inhibits HERG potassium channels.
Karle CA, Kreye VA, Thomas D, Röckl K, Kathöfer S, Zhang W, Kiehn J. Karle CA, et al. Among authors: thomas d. Cardiovasc Res. 2001 Feb 1;49(2):361-70. doi: 10.1016/s0008-6363(00)00265-0. Cardiovasc Res. 2001. PMID: 11164846
The antiarrhythmic drug BRL-32872.
Karle CA, Thomas D, Kiehn J. Karle CA, et al. Among authors: thomas d. Cardiovasc Drug Rev. 2002 Summer;20(2):111-20. doi: 10.1111/j.1527-3466.2002.tb00186.x. Cardiovasc Drug Rev. 2002. PMID: 12177689 Review.
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