Kimura T - Search Results

1

Synthesis and antiviral property of allophenylnorstatine-based HIV protease inhibitors incorporating D-cysteine derivatives as P2/P3 moieties.

Ami E, Nakahara K, Sato A, Nguyen JT, Hidaka K, Hamada Y, Nakatani S, Kimura T, Hayashi Y, Kiso Y. Ami E, et al. Among authors: kimura t. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4213-7. doi: 10.1016/j.bmcl.2007.05.039. Epub 2007 May 17. Bioorg Med Chem Lett. 2007. PMID: 17537628

2

New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration.

Hamada Y, Ohtake J, Sohma Y, Kimura T, Hayashi Y, Kiso Y. Hamada Y, et al. Among authors: kimura t. Bioorg Med Chem. 2002 Dec;10(12):4155-67. doi: 10.1016/s0968-0896(02)00322-x. Bioorg Med Chem. 2002. PMID: 12413869

3

An expedient synthesis of N(alpha)-protected-L-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease.

Rajesh S, Ami E, Kotake T, Kimura T, Hayashi Y, Kiso Y. Rajesh S, et al. Among authors: kimura t. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3615-7. doi: 10.1016/s0960-894x(02)00781-3. Bioorg Med Chem Lett. 2002. PMID: 12443788

4

Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere.

Hidaka K, Kimura T, Hayashi Y, McDaniel KF, Dekhtyar T, Colletti L, Kiso Y. Hidaka K, et al. Among authors: kimura t. Bioorg Med Chem Lett. 2003 Jan 6;13(1):93-6. doi: 10.1016/s0960-894x(02)00848-x. Bioorg Med Chem Lett. 2003. PMID: 12467624

5

Effect of the acyl groups on O-->N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor.

Hamada Y, Matsumoto H, Kimura T, Hayashi Y, Kiso Y. Hamada Y, et al. Among authors: kimura t. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2727-30. doi: 10.1016/s0960-894x(03)00576-6. Bioorg Med Chem Lett. 2003. PMID: 12873502

6

A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: design and synthesis of isotaxel.

Hayashi Y, Skwarczynski M, Hamada Y, Sohma Y, Kimura T, Kiso Y. Hayashi Y, et al. Among authors: kimura t. J Med Chem. 2003 Aug 28;46(18):3782-4. doi: 10.1021/jm034112n. J Med Chem. 2003. PMID: 12930140

7

Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage.

Sohma Y, Hayashi Y, Ito T, Matsumoto H, Kimura T, Kiso Y. Sohma Y, et al. Among authors: kimura t. J Med Chem. 2003 Sep 11;46(19):4124-35. doi: 10.1021/jm030009m. J Med Chem. 2003. PMID: 12954064

8

KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides.

Shuto D, Kasai S, Kimura T, Liu P, Hidaka K, Hamada T, Shibakawa S, Hayashi Y, Hattori C, Szabo B, Ishiura S, Kiso Y. Shuto D, et al. Among authors: kimura t. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4273-6. doi: 10.1016/j.bmcl.2003.09.053. Bioorg Med Chem Lett. 2003. PMID: 14643307

9

Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-->N intramolecular acyl migration: Design, synthesis and kinetic study.

Hamada Y, Matsumoto H, Yamaguchi S, Kimura T, Hayashi Y, Kiso Y. Hamada Y, et al. Among authors: kimura t. Bioorg Med Chem. 2004 Jan 2;12(1):159-70. doi: 10.1016/j.bmc.2003.10.026. Bioorg Med Chem. 2004. PMID: 14697781

10

KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine.

Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y. Kimura T, et al. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1527-31. doi: 10.1016/j.bmcl.2003.12.088. Bioorg Med Chem Lett. 2004. PMID: 15006396

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