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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM, Neeman M, Sessa WC, Dvorak HF, Benjamin LE. Phung TL, et al. Among authors: benjamin le. Cancer Cell. 2006 Aug;10(2):159-70. doi: 10.1016/j.ccr.2006.07.003. Cancer Cell. 2006. PMID: 16904613 Free PMC article.
RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.
Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, Kocher ON, Brown LF, Toker A, Prendergast GC, Benjamin LE. Kazerounian S, et al. Among authors: benjamin le. Cancer Res. 2013 Jan 1;73(1):50-61. doi: 10.1158/0008-5472.CAN-11-3055. Epub 2012 Nov 7. Cancer Res. 2013. PMID: 23135917 Free PMC article.
Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.
Phung TL, Du W, Xue Q, Ayyaswamy S, Gerald D, Antonello Z, Nhek S, Perruzzi CA, Acevedo I, Ramanna-Valmiki R, Rodriguez-Waitkus P, Enayati L, Hochman ML, Lev D, Geeganage S, Benjamin LE. Phung TL, et al. Among authors: benjamin le. Cancer Res. 2015 Jan 1;75(1):40-50. doi: 10.1158/0008-5472.CAN-13-2961. Epub 2014 Nov 11. Cancer Res. 2015. PMID: 25388284
Microvascular patterning is controlled by fine-tuning the Akt signal.
Sun JF, Phung T, Shiojima I, Felske T, Upalakalin JN, Feng D, Kornaga T, Dor T, Dvorak AM, Walsh K, Benjamin LE. Sun JF, et al. Among authors: benjamin le. Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):128-33. doi: 10.1073/pnas.0403198102. Epub 2004 Dec 20. Proc Natl Acad Sci U S A. 2005. PMID: 15611473 Free PMC article.
Akt promotes endocardial-mesenchyme transition.
Meadows KN, Iyer S, Stevens MV, Wang D, Shechter S, Perruzzi C, Camenisch TD, Benjamin LE. Meadows KN, et al. Among authors: benjamin le. J Angiogenes Res. 2009 Sep 21;1:2. doi: 10.1186/2040-2384-1-2. J Angiogenes Res. 2009. PMID: 19946410 Free PMC article.
86 results