Shackleton CHL - Search Results

1

11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function.

Walker EA, Ahmed A, Lavery GG, Tomlinson JW, Kim SY, Cooper MS, Ride JP, Hughes BA, Shackleton CHL, McKiernan P, Elias E, Chou JY, Stewart PM. Walker EA, et al. Among authors: shackleton chl. J Biol Chem. 2007 Sep 14;282(37):27030-27036. doi: 10.1074/jbc.M704144200. Epub 2007 Jun 22. J Biol Chem. 2007. PMID: 17588937 Free article.

2

Hexose-6-phosphate dehydrogenase knock-out mice lack 11 beta-hydroxysteroid dehydrogenase type 1-mediated glucocorticoid generation.

Lavery GG, Walker EA, Draper N, Jeyasuria P, Marcos J, Shackleton CH, Parker KL, White PC, Stewart PM. Lavery GG, et al. J Biol Chem. 2006 Mar 10;281(10):6546-51. doi: 10.1074/jbc.M512635200. Epub 2005 Dec 15. J Biol Chem. 2006. PMID: 16356929 Free article.

3

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.

Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W, Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC, Hewison M, Mason PJ, Connell JM, Shackleton CH, Stewart PM. Draper N, et al. Nat Genet. 2003 Aug;34(4):434-9. doi: 10.1038/ng1214. Nat Genet. 2003. PMID: 12858176

4

11beta-hydroxysteroid dehydrogenase type 1 activity in lean and obese males with type 2 diabetes mellitus.

Valsamakis G, Anwar A, Tomlinson JW, Shackleton CH, McTernan PG, Chetty R, Wood PJ, Banerjee AK, Holder G, Barnett AH, Stewart PM, Kumar S. Valsamakis G, et al. J Clin Endocrinol Metab. 2004 Sep;89(9):4755-61. doi: 10.1210/jc.2003-032240. J Clin Endocrinol Metab. 2004. PMID: 15356090

5

11beta-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone.

Cooper MS, Blumsohn A, Goddard PE, Bartlett WA, Shackleton CH, Eastell R, Hewison M, Stewart PM. Cooper MS, et al. J Clin Endocrinol Metab. 2003 Aug;88(8):3874-7. doi: 10.1210/jc.2003-022025. J Clin Endocrinol Metab. 2003. PMID: 12915682 Clinical Trial.

6

17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites.

Shackleton CH, Neres MS, Hughes BA, Stewart PM, Kater CE. Shackleton CH, et al. Steroids. 2008 Jul;73(6):652-6. doi: 10.1016/j.steroids.2008.02.001. Epub 2008 Feb 13. Steroids. 2008. PMID: 18355883

7

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.

Lavery GG, Walker EA, Tiganescu A, Ride JP, Shackleton CH, Tomlinson JW, Connell JM, Ray DW, Biason-Lauber A, Malunowicz EM, Arlt W, Stewart PM. Lavery GG, et al. J Clin Endocrinol Metab. 2008 Oct;93(10):3827-32. doi: 10.1210/jc.2008-0743. Epub 2008 Jul 15. J Clin Endocrinol Metab. 2008. PMID: 18628520 Free PMC article.

8

Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life.

Rogers SL, Hughes BA, Jones CA, Freedman L, Smart K, Taylor N, Stewart PM, Shackleton CH, Krone NP, Blissett J, Tomlinson JW. Rogers SL, et al. J Clin Endocrinol Metab. 2014 May;99(5):E821-31. doi: 10.1210/jc.2013-3254. Epub 2014 Feb 11. J Clin Endocrinol Metab. 2014. PMID: 24517145 Free article.

9

Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype.

Crowley RK, Hughes B, Gray J, McCarthy T, Hughes S, Shackleton CH, Crabtree N, Nightingale P, Stewart PM, Tomlinson JW. Crowley RK, et al. Eur J Endocrinol. 2014 Oct;171(4):433-42. doi: 10.1530/EJE-14-0256. Epub 2014 Jul 1. Eur J Endocrinol. 2014. PMID: 24986533

10

Increased central adiposity and decreased subcutaneous adipose tissue 11β-hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance-A longitudinal cohort study.

Crowley RK, Woods CP, Hughes BA, Gray J, McCarthy T, Taylor AE, Gathercole LL, Shackleton CHL, Crabtree N, Arlt W, Stewart PM, Tomlinson JW. Crowley RK, et al. Among authors: shackleton chl. Clin Endocrinol (Oxf). 2019 Jul;91(1):72-81. doi: 10.1111/cen.13939. Epub 2019 Apr 17. Clin Endocrinol (Oxf). 2019. PMID: 30667079

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