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Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED. Nagendran J, et al. Among authors: archer sl. Circulation. 2007 Jul 17;116(3):238-48. doi: 10.1161/CIRCULATIONAHA.106.655266. Epub 2007 Jul 2. Circulation. 2007. PMID: 17606845
Sildenafil: from the bench to the bedside.
Michelakis E, Tymchak W, Archer S. Michelakis E, et al. CMAJ. 2000 Oct 31;163(9):1171-5. CMAJ. 2000. PMID: 11079066 Free PMC article. Review.
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