Segaloff DL - Search Results

1

Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.

Zhang M, Tao YX, Ryan GL, Feng X, Fanelli F, Segaloff DL. Zhang M, et al. Among authors: segaloff dl. J Biol Chem. 2007 Aug 31;282(35):25527-39. doi: 10.1074/jbc.M703500200. Epub 2007 Jul 2. J Biol Chem. 2007. PMID: 17609213 Free article.

2

Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor.

Shinozaki H, Butnev V, Tao YX, Ang KL, Conti M, Segaloff DL. Shinozaki H, et al. Among authors: segaloff dl. J Clin Endocrinol Metab. 2003 Mar;88(3):1194-204. doi: 10.1210/jc.2002-021051. J Clin Endocrinol Metab. 2003. PMID: 12629106

3

Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor.

Tao YX, Johnson NB, Segaloff DL. Tao YX, et al. Among authors: segaloff dl. J Biol Chem. 2004 Feb 13;279(7):5904-14. doi: 10.1074/jbc.M311162200. Epub 2003 Oct 31. J Biol Chem. 2004. PMID: 14594799 Free article.

4

Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation.

Tao YX, Segaloff DL. Tao YX, et al. Among authors: segaloff dl. J Clin Endocrinol Metab. 2004 Aug;89(8):3936-42. doi: 10.1210/jc.2004-0367. J Clin Endocrinol Metab. 2004. PMID: 15292330

5

The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor.

Zhang M, Mizrachi D, Fanelli F, Segaloff DL. Zhang M, et al. Among authors: segaloff dl. J Biol Chem. 2005 Jul 15;280(28):26169-76. doi: 10.1074/jbc.M502102200. Epub 2005 May 20. J Biol Chem. 2005. PMID: 15908694 Free PMC article.

6

Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism.

Ryan GL, Feng X, d'Alva CB, Zhang M, Van Voorhis BJ, Pinto EM, Kubias AE, Antonini SR, Latronico AC, Segaloff DL. Ryan GL, et al. Among authors: segaloff dl. J Clin Endocrinol Metab. 2007 Jun;92(6):2312-7. doi: 10.1210/jc.2006-2086. Epub 2007 Mar 13. J Clin Endocrinol Metab. 2007. PMID: 17356048

7

An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.

Feng X, Müller T, Mizrachi D, Fanelli F, Segaloff DL. Feng X, et al. Among authors: segaloff dl. Endocrinology. 2008 Apr;149(4):1705-17. doi: 10.1210/en.2007-1341. Epub 2007 Dec 27. Endocrinology. 2008. PMID: 18162522 Free PMC article.

8

Bioluminescence resonance energy transfer studies reveal constitutive dimerization of the human lutropin receptor and a lack of correlation between receptor activation and the propensity for dimerization.

Guan R, Feng X, Wu X, Zhang M, Zhang X, Hébert TE, Segaloff DL. Guan R, et al. Among authors: segaloff dl. J Biol Chem. 2009 Mar 20;284(12):7483-94. doi: 10.1074/jbc.M809150200. Epub 2009 Jan 15. J Biol Chem. 2009. PMID: 19147490 Free PMC article.

9

A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization.

Zhang M, Feng X, Guan R, Hébert TE, Segaloff DL. Zhang M, et al. Among authors: segaloff dl. Cell Signal. 2009 Nov;21(11):1663-71. doi: 10.1016/j.cellsig.2009.07.003. Epub 2009 Jul 16. Cell Signal. 2009. PMID: 19616090 Free PMC article.

10

Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors.

Guan R, Wu X, Feng X, Zhang M, Hébert TE, Segaloff DL. Guan R, et al. Among authors: segaloff dl. Cell Signal. 2010 Feb;22(2):247-56. doi: 10.1016/j.cellsig.2009.09.023. Epub 2009 Sep 30. Cell Signal. 2010. PMID: 19800402 Free PMC article.

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