Koo EH - Search Results

1

Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.

Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Kukar T, et al. Among authors: koo eh. BMC Neurosci. 2007 Jul 24;8:54. doi: 10.1186/1471-2202-8-54. BMC Neurosci. 2007. PMID: 17650315 Free PMC article.

2

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.

Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE. Eriksen JL, et al. Among authors: koo eh. J Clin Invest. 2003 Aug;112(3):440-9. doi: 10.1172/JCI18162. J Clin Invest. 2003. PMID: 12897211 Free PMC article.

3

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.

Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE. Kukar T, et al. Among authors: koo eh. Nat Med. 2005 May;11(5):545-50. doi: 10.1038/nm1235. Epub 2005 Apr 17. Nat Med. 2005. PMID: 15834426

4

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Among authors: koo eh. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.

5

Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift.

Golde TE, Schneider LS, Koo EH. Golde TE, et al. Among authors: koo eh. Neuron. 2011 Jan 27;69(2):203-13. doi: 10.1016/j.neuron.2011.01.002. Neuron. 2011. PMID: 21262461 Free PMC article.

6

Steroids as γ-secretase modulators.

Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. Jung JI, et al. Among authors: koo eh. FASEB J. 2013 Sep;27(9):3775-85. doi: 10.1096/fj.12-225649. Epub 2013 May 28. FASEB J. 2013. PMID: 23716494 Free PMC article.

7

γ-Secretase inhibitors and modulators.

Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. Golde TE, et al. Among authors: koo eh. Biochim Biophys Acta. 2013 Dec;1828(12):2898-907. doi: 10.1016/j.bbamem.2013.06.005. Epub 2013 Jun 17. Biochim Biophys Acta. 2013. PMID: 23791707 Free PMC article. Review.

8

Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans.

Ling IF, Golde TE, Galasko DR, Koo EH. Ling IF, et al. Among authors: koo eh. Alzheimers Res Ther. 2015 Aug 5;7(1):55. doi: 10.1186/s13195-015-0137-y. eCollection 2015. Alzheimers Res Ther. 2015. PMID: 26244059 Free PMC article.

9

Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice.

Park SA, Chevallier N, Tejwani K, Hung MM, Maruyama H, Golde TE, Koo EH. Park SA, et al. Among authors: koo eh. Biochem Biophys Res Commun. 2016 Sep 9;478(1):286-292. doi: 10.1016/j.bbrc.2016.07.015. Epub 2016 Jul 15. Biochem Biophys Res Commun. 2016. PMID: 27425247

10

Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. Weggen S, et al. Among authors: koo eh. J Biol Chem. 2003 Aug 15;278(33):30748-54. doi: 10.1074/jbc.M304824200. Epub 2003 May 31. J Biol Chem. 2003. PMID: 12777371 Free article.

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