Aimová D - Search Results

1

The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism.

Aimová D, Svobodová L, Kotrbová V, Mrázová B, Hodek P, Hudecek J, Václavíková R, Frei E, Stiborová M. Aimová D, et al. Drug Metab Dispos. 2007 Oct;35(10):1926-34. doi: 10.1124/dmd.107.016048. Epub 2007 Jul 26. Drug Metab Dispos. 2007. PMID: 17656468

2

Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems.

Stiborová M, Borek-Dohalská L, Aimová D, Kotrbová V, Kukacková K, Janouchová K, Rupertová M, Ryslavá H, Hudecek J, Frei E. Stiborová M, et al. Among authors: aimova d. Gen Physiol Biophys. 2006 Sep;25(3):245-61. Gen Physiol Biophys. 2006. PMID: 17197724 Free article.

3

DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling.

Stiborová M, Breuer A, Aimová D, Stiborová-Rupertová M, Wiessler M, Frei E. Stiborová M, et al. Among authors: aimova d. Int J Cancer. 2003 Dec 20;107(6):885-90. doi: 10.1002/ijc.11511. Int J Cancer. 2003. PMID: 14601046

4

The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide.

Stiborová M, Sejbal J, Borek-Dohalská L, Aimová D, Poljaková J, Forsterová K, Rupertová M, Wiesner J, Hudecek J, Wiessler M, Frei E. Stiborová M, et al. Among authors: aimova d. Cancer Res. 2004 Nov 15;64(22):8374-80. doi: 10.1158/0008-5472.CAN-04-2202. Cancer Res. 2004. PMID: 15548707

5

Antitumor drug ellipticine inhibits the activities of rat hepatic cytochromes P450.

Aimová D, Stiborová M. Aimová D, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):437-40. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005. PMID: 16601806

6

Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes.

Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M. Kotrbová V, et al. Among authors: aimova d. Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:18-22. Neuro Endocrinol Lett. 2006. PMID: 17159771

7

DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells.

Poljaková J, Frei E, Gomez JE, Aimová D, Eckschlager T, Hrabeta J, Stiborová M. Poljaková J, et al. Among authors: aimova d. Cancer Lett. 2007 Jul 18;252(2):270-9. doi: 10.1016/j.canlet.2006.12.037. Epub 2007 Feb 16. Cancer Lett. 2007. PMID: 17306925

8

Formation and persistence of DNA adducts of anticancer drug ellipticine in rats.

Stiborová M, Rupertová M, Aimová D, Ryslavá H, Frei E. Stiborová M, et al. Among authors: aimova d. Toxicology. 2007 Jul 1;236(1-2):50-60. doi: 10.1016/j.tox.2007.03.026. Epub 2007 Apr 7. Toxicology. 2007. PMID: 17482743

9

Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2.

Aimová D, Poljaková J, Kotrbová V, Moserová M, Frei E, Arlt VM, Stiborová M. Aimová D, et al. Interdiscip Toxicol. 2008 Sep;1(2):160-8. doi: 10.2478/V10102-010-0033-z. Interdiscip Toxicol. 2008. PMID: 21218107 Free PMC article.

10

Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method.

Moserová M, Kotrbová V, Aimová D, Sulc M, Frei E, Stiborová M. Moserová M, et al. Among authors: aimova d. Interdiscip Toxicol. 2009 Dec;2(4):239-44. doi: 10.2478/v10102-009-0024-0. Epub 2009 Dec 28. Interdiscip Toxicol. 2009. PMID: 21217860 Free PMC article.

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