Kotrbová V - Search Results

1

The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism.

Aimová D, Svobodová L, Kotrbová V, Mrázová B, Hodek P, Hudecek J, Václavíková R, Frei E, Stiborová M. Aimová D, et al. Among authors: kotrbova v. Drug Metab Dispos. 2007 Oct;35(10):1926-34. doi: 10.1124/dmd.107.016048. Epub 2007 Jul 26. Drug Metab Dispos. 2007. PMID: 17656468

2

Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems.

Stiborová M, Borek-Dohalská L, Aimová D, Kotrbová V, Kukacková K, Janouchová K, Rupertová M, Ryslavá H, Hudecek J, Frei E. Stiborová M, et al. Among authors: kotrbova v. Gen Physiol Biophys. 2006 Sep;25(3):245-61. Gen Physiol Biophys. 2006. PMID: 17197724 Free article.

3

Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes.

Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M. Kotrbová V, et al. Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:18-22. Neuro Endocrinol Lett. 2006. PMID: 17159771

4

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

Stiborová M, Arlt VM, Henderson CJ, Wolf CR, Kotrbová V, Moserová M, Hudecek J, Phillips DH, Frei E. Stiborová M, et al. Among authors: kotrbova v. Toxicol Appl Pharmacol. 2008 Feb 1;226(3):318-27. doi: 10.1016/j.taap.2007.09.017. Epub 2007 Sep 26. Toxicol Appl Pharmacol. 2008. PMID: 17976674

5

Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.

Stiborova M, Moserova M, Mrazova B, Kotrbova V, Frei E. Stiborova M, et al. Among authors: kotrbova v. Neuro Endocrinol Lett. 2010;31 Suppl 2:26-35. Neuro Endocrinol Lett. 2010. PMID: 21187821

6

Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2.

Aimová D, Poljaková J, Kotrbová V, Moserová M, Frei E, Arlt VM, Stiborová M. Aimová D, et al. Among authors: kotrbova v. Interdiscip Toxicol. 2008 Sep;1(2):160-8. doi: 10.2478/V10102-010-0033-z. Interdiscip Toxicol. 2008. PMID: 21218107 Free PMC article.

7

Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.

Kotrbová V, Mrázová B, Moserová M, Martínek V, Hodek P, Hudeček J, Frei E, Stiborová M. Kotrbová V, et al. Biochem Pharmacol. 2011 Sep 15;82(6):669-80. doi: 10.1016/j.bcp.2011.06.003. Epub 2011 Jun 13. Biochem Pharmacol. 2011. PMID: 21683692

8

Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA.

Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M. Moserova M, et al. Among authors: kotrbova v. Neuro Endocrinol Lett. 2008 Oct;29(5):728-32. Neuro Endocrinol Lett. 2008. PMID: 18987592

9

Analysis of benzo[a]pyrene metabolites formed by rat hepatic microsomes using high pressure liquid chromatography: optimization of the method.

Moserová M, Kotrbová V, Aimová D, Sulc M, Frei E, Stiborová M. Moserová M, et al. Among authors: kotrbova v. Interdiscip Toxicol. 2009 Dec;2(4):239-44. doi: 10.2478/v10102-009-0024-0. Epub 2009 Dec 28. Interdiscip Toxicol. 2009. PMID: 21217860 Free PMC article.

10

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

Levová K, Moserová M, Kotrbová V, Sulc M, Henderson CJ, Wolf CR, Phillips DH, Frei E, Schmeiser HH, Mares J, Arlt VM, Stiborová M. Levová K, et al. Among authors: kotrbova v. Toxicol Sci. 2011 May;121(1):43-56. doi: 10.1093/toxsci/kfr050. Epub 2011 Feb 28. Toxicol Sci. 2011. PMID: 21362632 Free article.

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