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Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.
Kotrbová V, Mrázová B, Moserová M, Martínek V, Hodek P, Hudeček J, Frei E, Stiborová M. Kotrbová V, et al. Among authors: mrazova b. Biochem Pharmacol. 2011 Sep 15;82(6):669-80. doi: 10.1016/j.bcp.2011.06.003. Epub 2011 Jun 13. Biochem Pharmacol. 2011. PMID: 21683692