Stiborová M - Search Results

1

The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism.

Aimová D, Svobodová L, Kotrbová V, Mrázová B, Hodek P, Hudecek J, Václavíková R, Frei E, Stiborová M. Aimová D, et al. Among authors: stiborova m. Drug Metab Dispos. 2007 Oct;35(10):1926-34. doi: 10.1124/dmd.107.016048. Epub 2007 Jul 26. Drug Metab Dispos. 2007. PMID: 17656468

2

New selective inhibitors of cytochromes P450 2B and their application to antimutagenesis of tamoxifen.

Stiborová M, Borek-Dohalská L, Hodek P, Mráz J, Frei E. Stiborová M, et al. Arch Biochem Biophys. 2002 Jul 1;403(1):41-9. doi: 10.1016/S0003-9861(02)00259-X. Arch Biochem Biophys. 2002. PMID: 12061800

3

DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling.

Stiborová M, Breuer A, Aimová D, Stiborová-Rupertová M, Wiessler M, Frei E. Stiborová M, et al. Among authors: stiborova rupertova m. Int J Cancer. 2003 Dec 20;107(6):885-90. doi: 10.1002/ijc.11511. Int J Cancer. 2003. PMID: 14601046

4

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

Stiborová M, Frei E, Hodek P, Wiessler M, Schmeiser HH. Stiborová M, et al. Int J Cancer. 2005 Jan 10;113(2):189-97. doi: 10.1002/ijc.20564. Int J Cancer. 2005. PMID: 15386410

5

The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide.

Stiborová M, Sejbal J, Borek-Dohalská L, Aimová D, Poljaková J, Forsterová K, Rupertová M, Wiesner J, Hudecek J, Wiessler M, Frei E. Stiborová M, et al. Cancer Res. 2004 Nov 15;64(22):8374-80. doi: 10.1158/0008-5472.CAN-04-2202. Cancer Res. 2004. PMID: 15548707

6

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.

Stiborová M, Sopko B, Hodek P, Frei E, Schmeiser HH, Hudecek J. Stiborová M, et al. Cancer Lett. 2005 Nov 18;229(2):193-204. doi: 10.1016/j.canlet.2005.06.038. Epub 2005 Aug 24. Cancer Lett. 2005. PMID: 16125300

7

Antitumor drug ellipticine inhibits the activities of rat hepatic cytochromes P450.

Aimová D, Stiborová M. Aimová D, et al. Among authors: stiborova m. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):437-40. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005. PMID: 16601806

8

The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.

Stiborová M, Dracínská H, Hájková J, Kaderábková P, Frei E, Schmeiser HH, Soucek P, Phillips DH, Arlt VM. Stiborová M, et al. Drug Metab Dispos. 2006 Aug;34(8):1398-405. doi: 10.1124/dmd.106.009373. Epub 2006 May 19. Drug Metab Dispos. 2006. PMID: 16714372

9

Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine.

Stiborova M, Rupertova M, Schmeiser HH, Frei E. Stiborova M, et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. doi: 10.5507/bp.2006.002. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006. PMID: 16936898 Review.

10

Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes.

Kotrbová V, Aimová D, Brezinová A, Janouchová K, Poljaková J, Frei E, Stiborová M. Kotrbová V, et al. Among authors: stiborova m. Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:18-22. Neuro Endocrinol Lett. 2006. PMID: 17159771

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