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An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kälin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S. Lehmann SM, et al. Among authors: ploegh hl. Nat Neurosci. 2012 Jun;15(6):827-35. doi: 10.1038/nn.3113. Nat Neurosci. 2012. PMID: 22610069
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.
Maehr R, Mintern JD, Herman AE, Lennon-Duménil AM, Mathis D, Benoist C, Ploegh HL. Maehr R, et al. Among authors: ploegh hl. J Clin Invest. 2005 Oct;115(10):2934-43. doi: 10.1172/JCI25485. Epub 2005 Sep 22. J Clin Invest. 2005. PMID: 16184198 Free PMC article.
635 results