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2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB. Baxter EW, et al. Among authors: jordan ad. J Med Chem. 2007 Sep 6;50(18):4261-4. doi: 10.1021/jm0705408. Epub 2007 Aug 8. J Med Chem. 2007. PMID: 17685503
N-aryl-N'-benzylpiperazines as potential antipsychotic agents.
Reitz AB, Baxter EW, Bennett DJ, Codd EE, Jordan AD, Malloy EA, Maryanoff BE, McDonnell ME, Ortegon ME, Renzi MJ, et al. Reitz AB, et al. Among authors: jordan ad. J Med Chem. 1995 Oct 13;38(21):4211-22. doi: 10.1021/jm00021a010. J Med Chem. 1995. PMID: 7473548
Carbohydrate biguanides as potential hypoglycemic agents.
Reitz AB, Tuman RW, Marchione CS, Jordan AD Jr, Bowden CR, Maryanoff BE. Reitz AB, et al. Among authors: jordan ad jr. J Med Chem. 1989 Sep;32(9):2110-6. doi: 10.1021/jm00129a015. J Med Chem. 1989. PMID: 2769683
Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site.
Maryanoff BE, O'Neill JC, McComsey DF, Yabut SC, Luci DK, Jordan AD Jr, Masucci JA, Jones WJ, Abad MC, Gibbs AC, Petrounia I. Maryanoff BE, et al. Among authors: jordan ad jr. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43. doi: 10.1021/ml200070g. eCollection 2011 Jul 14. ACS Med Chem Lett. 2011. PMID: 24900346 Free PMC article.
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic.
Dubinsky B, Vaidya AH, Rosenthal DI, Hochman C, Crooke JJ, DeLuca S, DeVine A, Cheo-Isaacs CT, Carter AR, Jordan AD, Reitz AB, Shank RP. Dubinsky B, et al. Among authors: jordan ad. J Pharmacol Exp Ther. 2002 Nov;303(2):777-90. doi: 10.1124/jpet.102.036954. J Pharmacol Exp Ther. 2002. PMID: 12388665
19 results