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Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.
Bhattacharya A, Scott BP, Nasser N, Ao H, Maher MP, Dubin AE, Swanson DM, Shankley NP, Wickenden AD, Chaplan SR. Bhattacharya A, et al. Among authors: chaplan sr. J Pharmacol Exp Ther. 2007 Nov;323(2):665-74. doi: 10.1124/jpet.107.127258. Epub 2007 Aug 9. J Pharmacol Exp Ther. 2007. PMID: 17690251
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C, Lord B, Gonzales L, Hoey K, Rizzolio M, Bogenstaetter M, Codd EE, Lee DH, Zhang SP, Chaplan SR, Carruthers NI. Swanson DM, et al. Among authors: chaplan sr. J Med Chem. 2005 Mar 24;48(6):1857-72. doi: 10.1021/jm0495071. J Med Chem. 2005. PMID: 15771431
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.
Ghilardi JR, Röhrich H, Lindsay TH, Sevcik MA, Schwei MJ, Kubota K, Halvorson KG, Poblete J, Chaplan SR, Dubin AE, Carruthers NI, Swanson D, Kuskowski M, Flores CM, Julius D, Mantyh PW. Ghilardi JR, et al. Among authors: chaplan sr. J Neurosci. 2005 Mar 23;25(12):3126-31. doi: 10.1523/JNEUROSCI.3815-04.2005. J Neurosci. 2005. PMID: 15788769 Free PMC article.
The role of pacemaker currents in neuropathic pain.
Brown SM, Dubin AE, Chaplan SR. Brown SM, et al. Among authors: chaplan sr. Pain Pract. 2004 Sep;4(3):182-93. doi: 10.1111/j.1533-2500.2004.04303.x. Pain Pract. 2004. PMID: 17173600
Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat.
Luo L, Chang L, Brown SM, Ao H, Lee DH, Higuera ES, Dubin AE, Chaplan SR. Luo L, et al. Among authors: chaplan sr. Neuroscience. 2007 Feb 23;144(4):1477-85. doi: 10.1016/j.neuroscience.2006.10.048. Epub 2006 Dec 29. Neuroscience. 2007. PMID: 17196750
Previously, we documented that systemic administration of ZD7288, a specific blocker of pacemaker current (I(h)), decreased ectopic activity in dorsal root ganglion (DRG) and reversed tactile allodynia in spinal nerve ligated (SNL) rats [Chaplan SR, Guo HQ, Lee DH, …
Previously, we documented that systemic administration of ZD7288, a specific blocker of pacemaker current (I(h)), decreased ectopic activity …
65 results