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Page 1
Targeting oncogenic Ras.
Diaz-Flores E, Shannon K. Diaz-Flores E, et al. Genes Dev. 2007 Aug 15;21(16):1989-92. doi: 10.1101/gad.1587907. Genes Dev. 2007. PMID: 17699748 Free article. Review. No abstract available.
Abnormal hematopoiesis in Gab2 mutant mice.
Zhang Y, Diaz-Flores E, Li G, Wang Z, Kang Z, Haviernikova E, Rowe S, Qu CK, Tse W, Shannon KM, Bunting KD. Zhang Y, et al. Blood. 2007 Jul 1;110(1):116-24. doi: 10.1182/blood-2006-11-060707. Epub 2007 Mar 20. Blood. 2007. PMID: 17374739 Free PMC article.
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.
Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K. Lauchle JO, et al. Nature. 2009 Sep 17;461(7262):411-4. doi: 10.1038/nature08279. Epub 2009 Sep 2. Nature. 2009. PMID: 19727076 Free PMC article.
Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.
Jain N, Curran E, Iyengar NM, Diaz-Flores E, Kunnavakkam R, Popplewell L, Kirschbaum MH, Karrison T, Erba HP, Green M, Poire X, Koval G, Shannon K, Reddy PL, Joseph L, Atallah EL, Dy P, Thomas SP, Smith SE, Doyle LA, Stadler WM, Larson RA, Stock W, Odenike O. Jain N, et al. Clin Cancer Res. 2014 Jan 15;20(2):490-8. doi: 10.1158/1078-0432.CCR-13-1311. Epub 2013 Oct 31. Clin Cancer Res. 2014. PMID: 24178622 Free PMC article. Clinical Trial.
NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.
Sachs Z, LaRue RS, Nguyen HT, Sachs K, Noble KE, Mohd Hassan NA, Diaz-Flores E, Rathe SK, Sarver AL, Bendall SC, Ha NA, Diers MD, Nolan GP, Shannon KM, Largaespada DA. Sachs Z, et al. Among authors: diaz flores e. Blood. 2014 Nov 20;124(22):3274-83. doi: 10.1182/blood-2013-08-521708. Epub 2014 Oct 14. Blood. 2014. PMID: 25316678 Free PMC article.
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. Zhao Z, et al. Among authors: diaz flores e. Nat Genet. 2015 May;47(5):539-43. doi: 10.1038/ng.3251. Epub 2015 Mar 30. Nat Genet. 2015. PMID: 25822087 Free PMC article.
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