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Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.
Teng M, Johnson MD, Thomas C, Kiel D, Lakis JN, Kercher T, Aytes S, Kostrowicki J, Bhumralkar D, Truesdale L, May J, Sidelman U, Kodra JT, Jørgensen AS, Olesen PH, de Jong JC, Madsen P, Behrens C, Pettersson I, Knudsen LB, Holst JJ, Lau J. Teng M, et al. Among authors: holst jj. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5472-8. doi: 10.1016/j.bmcl.2007.06.086. Epub 2007 Jul 4. Bioorg Med Chem Lett. 2007. PMID: 17827014
Small-molecule agonists for the glucagon-like peptide 1 receptor.
Knudsen LB, Kiel D, Teng M, Behrens C, Bhumralkar D, Kodra JT, Holst JJ, Jeppesen CB, Johnson MD, de Jong JC, Jorgensen AS, Kercher T, Kostrowicki J, Madsen P, Olesen PH, Petersen JS, Poulsen F, Sidelmann UG, Sturis J, Truesdale L, May J, Lau J. Knudsen LB, et al. Among authors: holst jj. Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):937-42. doi: 10.1073/pnas.0605701104. Epub 2007 Jan 9. Proc Natl Acad Sci U S A. 2007. PMID: 17213325 Free PMC article.
Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells.
Elmelund E, Galsgaard KD, Johansen CD, Trammell SAJ, Bomholt AB, Winther-Sørensen M, Hunt JE, Sørensen CM, Kruse T, Lau JF, Grevengoed TJ, Holst JJ, Wewer Albrechtsen NJ. Elmelund E, et al. Among authors: holst jj. iScience. 2022 Oct 6;25(11):105296. doi: 10.1016/j.isci.2022.105296. eCollection 2022 Nov 18. iScience. 2022. PMID: 36325048 Free PMC article.
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
Galsgaard KD, Elmelund E, Johansen CD, Bomholt AB, Kizilkaya HS, Ceutz F, Hunt JE, Kissow H, Winther-Sørensen M, Sørensen CM, Kruse T, Lau JF, Rosenkilde MM, Ørskov C, Christoffersen C, Holst JJ, Wewer Albrechtsen NJ. Galsgaard KD, et al. Among authors: holst jj. Mol Metab. 2022 Dec;66:101639. doi: 10.1016/j.molmet.2022.101639. Epub 2022 Nov 15. Mol Metab. 2022. PMID: 36400402 Free PMC article.
Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial).
Klausen MK, Kuzey T, Pedersen JN, Justesen SK, Rasmussen L, Knorr UB, Mason G, Ekstrøm CT, Holst JJ, Koob G, Benveniste H, Volkow ND, Knudsen GM, Vilsbøll T, Fink-Jensen A. Klausen MK, et al. Among authors: holst jj. BMJ Open. 2025 Jan 8;15(1):e086454. doi: 10.1136/bmjopen-2024-086454. BMJ Open. 2025. PMID: 39779270 Free article.
Metabolic and Hormonal Responses to Isomaltulose Ingestion Before or During Sustained Submaximal Exercise in Adults with Type 1 Diabetes Using Automated Insulin Delivery Systems.
McCarthy OM, Christensen MB, Tawfik S, Kristensen KB, Hartmann B, Holst JJ, Schmidt S, Nørgaard K, Bracken RM. McCarthy OM, et al. Among authors: holst jj. Nutrients. 2024 Nov 28;16(23):4098. doi: 10.3390/nu16234098. Nutrients. 2024. PMID: 39683492 Free PMC article. Clinical Trial.
Human subjects with impaired beta-cell function and glucose tolerance have higher levels of intra-islet intact GLP-1.
Mezza T, Wewer Albrechtsen NJ, Di Giuseppe G, Ferraro PM, Soldovieri L, Ciccarelli G, Brunetti M, Quero G, Alfieri S, Nista EC, Gasbarrini A, Tondolo V, Mari A, Pontecorvi A, Giaccari A, Holst JJ. Mezza T, et al. Among authors: holst jj. Metabolism. 2025 Feb;163:156087. doi: 10.1016/j.metabol.2024.156087. Epub 2024 Dec 1. Metabolism. 2025. PMID: 39626843 Free article.
Replacing dietary carbohydrate with protein and fat improves lipoprotein subclass profile and liver fat in type 2 diabetes independent of body weight: evidence from 2 randomized controlled trials.
Thomsen MN, Skytte MJ, Samkani A, Weber P, Fenger M, Frystyk J, Hansen E, Holst JJ, Madsbad S, Magkos F, Thomsen HS, Walzem RL, Haugaard SB, Krarup T. Thomsen MN, et al. Among authors: holst jj. Am J Clin Nutr. 2024 Nov 29:S0002-9165(24)01425-4. doi: 10.1016/j.ajcnut.2024.11.030. Online ahead of print. Am J Clin Nutr. 2024. PMID: 39617302 Free article.
1,783 results