Jin Y - Search Results

1

Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9).

Cooper WC, Jin Y, Penning TM. Cooper WC, et al. Among authors: jin y. J Biol Chem. 2007 Nov 16;282(46):33484-33493. doi: 10.1074/jbc.M703414200. Epub 2007 Sep 11. J Biol Chem. 2007. PMID: 17848571 Free article.

2

Examination of the differences in structure-function of human and rat 3alpha-hydroxysteroid dehydrogenase.

Jin Y, Cooper WC, Penning TM. Jin Y, et al. Chem Biol Interact. 2003 Feb 1;143-144:383-92. doi: 10.1016/s0009-2797(02)00207-7. Chem Biol Interact. 2003. PMID: 12604225

3

Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.

Penning TM, Jin Y, Heredia VV, Lewis M. Penning TM, et al. Among authors: jin y. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):247-55. doi: 10.1016/s0960-0760(03)00236-x. J Steroid Biochem Mol Biol. 2003. PMID: 12943710 Review.

4

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B, Penning TM. Steckelbroeck S, et al. Among authors: jin y. J Biol Chem. 2004 Mar 12;279(11):10784-95. doi: 10.1074/jbc.M313308200. Epub 2003 Dec 12. J Biol Chem. 2004. PMID: 14672942 Free article.

5

Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step.

Heredia VV, Cooper WC, Kruger RG, Jin Y, Penning TM. Heredia VV, et al. Among authors: jin y. Biochemistry. 2004 May 18;43(19):5832-41. doi: 10.1021/bi0499563. Biochemistry. 2004. PMID: 15134457

6

Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): insights into positional and stereochemical preferences.

Jin Y, Penning TM. Jin Y, et al. Steroids. 2006 May;71(5):380-91. doi: 10.1016/j.steroids.2005.12.002. Epub 2006 Feb 7. Steroids. 2006. PMID: 16455123

7

Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens.

Jin Y, Penning TM. Jin Y, et al. Biochemistry. 2006 Oct 31;45(43):13054-63. doi: 10.1021/bi060591r. Biochemistry. 2006. PMID: 17059222 Free PMC article.

8

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

Jin Y, Duan L, Lee SH, Kloosterboer HJ, Blair IA, Penning TM. Jin Y, et al. J Biol Chem. 2009 Apr 10;284(15):10013-22. doi: 10.1074/jbc.M809465200. Epub 2009 Feb 12. J Biol Chem. 2009. PMID: 19218247 Free PMC article.

9

Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols.

Zhang L, Jin Y, Chen M, Huang M, Harvey RG, Blair IA, Penning TM. Zhang L, et al. Among authors: jin y. J Biol Chem. 2011 Jul 22;286(29):25644-54. doi: 10.1074/jbc.M111.240739. Epub 2011 May 27. J Biol Chem. 2011. PMID: 21622560 Free PMC article.

10

Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.

Adeniji AO, Twenter BM, Byrns MC, Jin Y, Chen M, Winkler JD, Penning TM. Adeniji AO, et al. Among authors: jin y. J Med Chem. 2012 Mar 8;55(5):2311-23. doi: 10.1021/jm201547v. Epub 2012 Feb 15. J Med Chem. 2012. PMID: 22263837 Free PMC article.

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