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NT-702 (parogrelil hydrochloride, NM-702), a novel and potent phosphodiesterase inhibitor, improves reduced walking distance and lowered hindlimb plantar surface temperature in a rat experimental intermittent claudication model.
Ishiwata N, Noguchi K, Kawanishi M, Asakura Y, Hori M, Mitani A, Ito Y, Takahashi K, Nishiyama H, Shudo N, Takahashi S, Takahashi K, Tsuruzoe N, Nakaike S. Ishiwata N, et al. Among authors: mitani a. Life Sci. 2007 Sep 1;81(12):970-8. doi: 10.1016/j.lfs.2007.07.025. Epub 2007 Aug 8. Life Sci. 2007. PMID: 17850826
HNS-32, a novel azulene-1-carboxamidine derivative, inhibits nifedipine-sensitive and -insensitive contraction of the isolated rabbit aorta.
Tanaka Y, Mitani A, Igarashi T, Someya S, Otsuka K, Imai T, Yamaki F, Tanaka H, Saitoh M, Nakazawa T, Noguchi K, Hashimoto K, Shigenobu K. Tanaka Y, et al. Among authors: mitani a. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):344-52. doi: 10.1007/s002100000368. Naunyn Schmiedebergs Arch Pharmacol. 2001. PMID: 11284450
Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis.
Takeuchi T, Hayashi M, Tamita T, Nomura Y, Kojima N, Mitani A, Takeda T, Hitaka K, Kato Y, Kamitani M, Mima M, Toki H, Ohkubo M, Nozoe A, Kakinuma H. Takeuchi T, et al. Among authors: mitani a. J Med Chem. 2022 Jun 23;65(12):8493-8510. doi: 10.1021/acs.jmedchem.2c00613. Epub 2022 Jun 10. J Med Chem. 2022. PMID: 35687819
365 results