Galley G - Search Results

1

Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.

Peters JU, Galley G, Jacobsen H, Czech C, David-Pierson P, Kitas EA, Ozmen L. Peters JU, et al. Among authors: galley g. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5918-23. doi: 10.1016/j.bmcl.2007.07.078. Epub 2007 Aug 22. Bioorg Med Chem Lett. 2007. PMID: 17869099

2

Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors.

Kitas EA, Galley G, Jakob-Roetne R, Flohr A, Wostl W, Mauser H, Alker AM, Czech C, Ozmen L, David-Pierson P, Reinhardt D, Jacobsen H. Kitas EA, et al. Among authors: galley g. Bioorg Med Chem Lett. 2008 Jan 1;18(1):304-8. doi: 10.1016/j.bmcl.2007.10.074. Epub 2007 Nov 5. Bioorg Med Chem Lett. 2008. PMID: 17983746

3

Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists.

Hoffmann T, Bös M, Stadler H, Schnider P, Hunkeler W, Godel T, Galley G, Ballard TM, Higgins GA, Poli SM, Sleight AJ. Hoffmann T, et al. Among authors: galley g. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5. doi: 10.1016/j.bmcl.2005.11.047. Epub 2005 Dec 5. Bioorg Med Chem Lett. 2006. PMID: 16332435

4

Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.

Galley G, Beurier A, Décoret G, Goergler A, Hutter R, Mohr S, Pähler A, Schmid P, Türck D, Unger R, Zbinden KG, Hoener MC, Norcross RD. Galley G, et al. ACS Med Chem Lett. 2015 Dec 30;7(2):192-7. doi: 10.1021/acsmedchemlett.5b00449. eCollection 2016 Feb 11. ACS Med Chem Lett. 2015. PMID: 26985297 Free PMC article.

5

Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012.

Galley G, Stalder H, Goergler A, Hoener MC, Norcross RD. Galley G, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. doi: 10.1016/j.bmcl.2012.06.060. Epub 2012 Jun 23. Bioorg Med Chem Lett. 2012. PMID: 22795332

6

High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.

Röver S, Adam G, Cesura AM, Galley G, Jenck F, Monsma FJ Jr, Wichmann J, Dautzenberg FM. Röver S, et al. Among authors: galley g. J Med Chem. 2000 Apr 6;43(7):1329-38. doi: 10.1021/jm991129q. J Med Chem. 2000. PMID: 10753470

7

Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.

Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann K, Haass C, Steiner H. Kretner B, et al. Among authors: galley g. J Biol Chem. 2011 Apr 29;286(17):15240-51. doi: 10.1074/jbc.M110.213587. Epub 2011 Feb 25. J Biol Chem. 2011. PMID: 21357415 Free PMC article.

8

ROCK: the Roche medicinal chemistry knowledge application - design, use and impact.

Mayweg A, Hofer U, Schnider P, Agnetti F, Galley G, Mattei P, Lucas M, Boehm HJ. Mayweg A, et al. Among authors: galley g. Drug Discov Today. 2011 Aug;16(15-16):691-6. doi: 10.1016/j.drudis.2011.03.005. Epub 2011 Mar 23. Drug Discov Today. 2011. PMID: 21439402

9

Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine.

Revel FG, Meyer CA, Bradaia A, Jeanneau K, Calcagno E, André CB, Haenggi M, Miss MT, Galley G, Norcross RD, Invernizzi RW, Wettstein JG, Moreau JL, Hoener MC. Revel FG, et al. Among authors: galley g. Neuropsychopharmacology. 2012 Nov;37(12):2580-92. doi: 10.1038/npp.2012.109. Epub 2012 Jul 4. Neuropsychopharmacology. 2012. PMID: 22763617 Free PMC article.

10

A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.

Revel FG, Moreau JL, Pouzet B, Mory R, Bradaia A, Buchy D, Metzler V, Chaboz S, Groebke Zbinden K, Galley G, Norcross RD, Tuerck D, Bruns A, Morairty SR, Kilduff TS, Wallace TL, Risterucci C, Wettstein JG, Hoener MC. Revel FG, et al. Among authors: galley g. Mol Psychiatry. 2013 May;18(5):543-56. doi: 10.1038/mp.2012.57. Epub 2012 May 29. Mol Psychiatry. 2013. PMID: 22641180

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