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Ribozymes as tools for therapeutic target validation in arthritis.
Jarvis TC, Bouhana KS, Lesch ME, Brown SA, Parry TJ, Schrier DJ, Hunt SW 3rd, Pavco PA, Flory CM. Jarvis TC, et al. Among authors: schrier dj. J Immunol. 2000 Jul 1;165(1):493-8. doi: 10.4049/jimmunol.165.1.493. J Immunol. 2000. PMID: 10861088
Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.
Boileau C, Martel-Pelletier J, Brunet J, Tardif G, Schrier D, Flory C, El-Kattan A, Boily M, Pelletier JP. Boileau C, et al. Arthritis Rheum. 2005 Feb;52(2):488-500. doi: 10.1002/art.20809. Arthritis Rheum. 2005. PMID: 15693013 Free article.
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