Diehl TS - Search Results

1

Active gamma-secretase complexes contain only one of each component.

Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Sato T, et al. Among authors: diehl ts. J Biol Chem. 2007 Nov 23;282(47):33985-93. doi: 10.1074/jbc.M705248200. Epub 2007 Oct 2. J Biol Chem. 2007. PMID: 17911105 Free article.

2

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.

Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Esler WP, et al. Among authors: diehl ts. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. doi: 10.1073/pnas.052436599. Epub 2002 Feb 26. Proc Natl Acad Sci U S A. 2002. PMID: 11867728 Free PMC article.

3

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Kimberly WT, et al. Biochemistry. 2003 Jan 14;42(1):137-44. doi: 10.1021/bi026888g. Biochemistry. 2003. PMID: 12515548

4

Designed helical peptides inhibit an intramembrane protease.

Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, Hyman BT, Wolfe MS. Das C, et al. Among authors: diehl ts. J Am Chem Soc. 2003 Oct 1;125(39):11794-5. doi: 10.1021/ja037131v. J Am Chem Soc. 2003. PMID: 14505382

5

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.

Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS. Sato T, et al. Among authors: diehl ts. Biochemistry. 2006 Jul 18;45(28):8649-56. doi: 10.1021/bi060597g. Biochemistry. 2006. PMID: 16834339

6

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Wolfe MS, et al. Among authors: diehl ts. Nature. 1999 Apr 8;398(6727):513-7. doi: 10.1038/19077. Nature. 1999. PMID: 10206644

7

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Among authors: diehl ts. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808

8

Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design.

Moore CL, Leatherwood DD, Diehl TS, Selkoe DJ, Wolfe MS. Moore CL, et al. Among authors: diehl ts. J Med Chem. 2000 Sep 7;43(18):3434-42. doi: 10.1021/jm000100f. J Med Chem. 2000. PMID: 10978191

9

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. Wolfe MS, et al. Among authors: diehl ts. J Med Chem. 1998 Jan 1;41(1):6-9. doi: 10.1021/jm970621b. J Med Chem. 1998. PMID: 9438016 No abstract available.

10

Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors.

Moore CL, Diehl TS, Selkoe DJ, Wolfe MS. Moore CL, et al. Among authors: diehl ts. Ann N Y Acad Sci. 2000;920:197-205. doi: 10.1111/j.1749-6632.2000.tb06922.x. Ann N Y Acad Sci. 2000. PMID: 11193150

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