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Active gamma-secretase complexes contain only one of each component.
Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Sato T, et al. Among authors: ihara y. J Biol Chem. 2007 Nov 23;282(47):33985-93. doi: 10.1074/jbc.M705248200. Epub 2007 Oct 2. J Biol Chem. 2007. PMID: 17911105 Free article.
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, Nishimura M. Nakaya Y, et al. Among authors: ihara y. J Biol Chem. 2005 May 13;280(19):19070-7. doi: 10.1074/jbc.M501130200. Epub 2005 Mar 10. J Biol Chem. 2005. PMID: 15764596 Free article.
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A. Shimojo M, et al. Among authors: ihara y. J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21. J Biol Chem. 2008. PMID: 18430735 Free article.
Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3.
Kang MS, Baek SH, Chun YS, Moore AZ, Landman N, Berman D, Yang HO, Morishima-Kawashima M, Osawa S, Funamoto S, Ihara Y, Di Paolo G, Park JH, Chung S, Kim TW. Kang MS, et al. Among authors: ihara y. J Biol Chem. 2013 Jul 19;288(29):20868-20882. doi: 10.1074/jbc.M112.445734. Epub 2013 May 30. J Biol Chem. 2013. PMID: 23723072 Free PMC article.
γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.
Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S, Ihara Y. Kakuda N, et al. Among authors: ihara y. Am J Pathol. 2020 Jun;190(6):1323-1331. doi: 10.1016/j.ajpath.2020.02.009. Epub 2020 Mar 20. Am J Pathol. 2020. PMID: 32201261 Free article.
718 results