Adams DR - Search Results

1

2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: a new class of protein tyrosine phosphatase 1B inhibitors.

Adams DR, Abraham A, Asano J, Breslin C, Dick CA, Ixkes U, Johnston BF, Johnston D, Kewnay J, Mackay SP, MacKenzie SJ, McFarlane M, Mitchell L, Spinks D, Takano Y. Adams DR, et al. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6579-83. doi: 10.1016/j.bmcl.2007.09.069. Epub 2007 Sep 25. Bioorg Med Chem Lett. 2007. PMID: 17931864

2

Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.

Adams DR, Tawati S, Berretta G, Rivas PL, Baiget J, Jiang Z, Alsfouk A, Mackay SP, Pyne NJ, Pyne S. Adams DR, et al. J Med Chem. 2019 Apr 11;62(7):3658-3676. doi: 10.1021/acs.jmedchem.9b00162. Epub 2019 Mar 27. J Med Chem. 2019. PMID: 30889352 Free article.

3

Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.

Allcock RW, Blakli H, Jiang Z, Johnston KA, Morgan KM, Rosair GM, Iwase K, Kohno Y, Adams DR. Allcock RW, et al. Among authors: adams dr. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3307-12. doi: 10.1016/j.bmcl.2011.04.021. Epub 2011 Apr 13. Bioorg Med Chem Lett. 2011. PMID: 21530250

4

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules.

Andrews PD, Becroft M, Aspegren A, Gilmour J, James MJ, McRae S, Kime R, Allcock RW, Abraham A, Jiang Z, Strehl R, Mountford JC, Milligan G, Houslay MD, Adams DR, Frearson JA. Andrews PD, et al. Among authors: adams dr. Biochem J. 2010 Nov 15;432(1):21-33. doi: 10.1042/BJ20101022. Biochem J. 2010. PMID: 20854259

5

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).

Day JP, Lindsay B, Riddell T, Jiang Z, Allcock RW, Abraham A, Sookup S, Christian F, Bogum J, Martin EK, Rae RL, Anthony D, Rosair GM, Houslay DM, Huston E, Baillie GS, Klussmann E, Houslay MD, Adams DR. Day JP, et al. Among authors: adams dr. J Med Chem. 2011 May 12;54(9):3331-47. doi: 10.1021/jm200070e. Epub 2011 Apr 13. J Med Chem. 2011. PMID: 21456625

6

Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration.

Ochiai K, Takita S, Kojima A, Eiraku T, Iwase K, Kishi T, Ohinata A, Yageta Y, Yasue T, Adams DR, Kohno Y. Ochiai K, et al. Among authors: adams dr. Bioorg Med Chem Lett. 2013 Jan 1;23(1):375-81. doi: 10.1016/j.bmcl.2012.08.121. Epub 2012 Nov 9. Bioorg Med Chem Lett. 2013. PMID: 23200255

7

Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.

Burton P, Adams DR, Abraham A, Allcock RW, Jiang Z, McCahill A, Gilmour J, McAbney J, Kaupisch A, Kane NM, Baillie GS, Baker AH, Milligan G, Houslay MD, Mountford JC. Burton P, et al. Among authors: adams dr. Biochem J. 2010 Dec 15;432(3):575-84. doi: 10.1042/BJ20100726. Biochem J. 2010. PMID: 20923411

8

Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.

Adams DR, Pyne S, Pyne NJ. Adams DR, et al. Cell Signal. 2020 Dec;76:109806. doi: 10.1016/j.cellsig.2020.109806. Epub 2020 Oct 7. Cell Signal. 2020. PMID: 33035646 Free article. Review.

9

Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones.

Johnston KA, Allcock RW, Jiang Z, Collier ID, Blakli H, Rosair GM, Bailey PD, Morgan KM, Kohno Y, Adams DR. Johnston KA, et al. Among authors: adams dr. Org Biomol Chem. 2008 Jan 7;6(1):175-86. doi: 10.1039/b713638b. Epub 2007 Nov 22. Org Biomol Chem. 2008. PMID: 18075664

10

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells.

Burton P, Adams DR, Abraham A, Allcock RW, Jiang Z, McCahill A, Gilmour J, McAbney J, Kane NM, Baillie GS, McKenzie FR, Baker AH, Houslay MD, Mountford JC, Milligan G. Burton P, et al. Among authors: adams dr. Biochem Soc Trans. 2010 Aug;38(4):1058-61. doi: 10.1042/BST0381058. Biochem Soc Trans. 2010. PMID: 20659003 Review.

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