Freeman S - Search Results

1

An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia.

Poucher SM, Freeman S, Loxham SJ, Convey G, Bartlett JB, De Schoolmeester J, Teague J, Walker M, Turnbull AV, Charles AD, Carey F, Berg S. Poucher SM, et al. Among authors: freeman s. Br J Pharmacol. 2007 Dec;152(8):1239-47. doi: 10.1038/sj.bjp.0707502. Epub 2007 Oct 15. Br J Pharmacol. 2007. PMID: 17934512 Free PMC article.

2

Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme.

Freeman S, Bartlett JB, Convey G, Hardern I, Teague JL, Loxham SJ, Allen JM, Poucher SM, Charles AD. Freeman S, et al. Br J Pharmacol. 2006 Nov;149(6):775-85. doi: 10.1038/sj.bjp.0706925. Epub 2006 Oct 3. Br J Pharmacol. 2006. PMID: 17016495 Free PMC article.

3

Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats.

Arden C, Green AR, Hampson LJ, Aiston S, Härndahl L, Greenberg CC, Brady MJ, Freeman S, Poucher SM, Agius L. Arden C, et al. Among authors: freeman s. FEBS J. 2006 May;273(9):1989-99. doi: 10.1111/j.1742-4658.2006.05215.x. FEBS J. 2006. PMID: 16640562 Free article.

4

The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation.

Green AR, Aiston S, Greenberg CC, Freeman S, Poucher SM, Brady MJ, Agius L. Green AR, et al. Among authors: freeman s. J Biol Chem. 2004 Nov 5;279(45):46474-82. doi: 10.1074/jbc.M405660200. Epub 2004 Aug 18. J Biol Chem. 2004. PMID: 15322104 Free article.

5

Inhibition of squalene synthase in vitro by 3-(biphenyl-4-yl)-quinuclidine.

Ward WH, Holdgate GA, Freeman S, McTaggart F, Girdwood PA, Davidson RG, Mallion KB, Brown GR, Eakin MA. Ward WH, et al. Among authors: freeman s. Biochem Pharmacol. 1996 Jun 14;51(11):1489-501. doi: 10.1016/0006-2952(96)00090-1. Biochem Pharmacol. 1996. PMID: 8630090

6

Inhibition of squalene synthase of rat liver by novel 3' substituted quinuclidines.

McTaggart F, Brown GR, Davidson RG, Freeman S, Holdgate GA, Mallion KB, Mirrlees DJ, Smith GJ, Ward WH. McTaggart F, et al. Among authors: freeman s. Biochem Pharmacol. 1996 Jun 14;51(11):1477-87. doi: 10.1016/0006-2952(96)00089-5. Biochem Pharmacol. 1996. PMID: 8630089

7

Phenoxypropylamines: a new series of squalene synthase inhibitors.

Brown GR, Butlin RJ, Chapman S, Eakin MA, Foubister AJ, Freeman S, Griffiths D, Harrison PJ, Johnson MC, Mallion KB, et al. Brown GR, et al. Among authors: freeman s. J Med Chem. 1995 Oct 13;38(21):4157-60. doi: 10.1021/jm00021a003. J Med Chem. 1995. PMID: 7473541 No abstract available.

8

Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.

Brown GR, Clarke DS, Foubister AJ, Freeman S, Harrison PJ, Johnson MC, Mallion KB, McCormick J, McTaggart F, Reid AC, Smith GJ, Taylor MJ. Brown GR, et al. Among authors: freeman s. J Med Chem. 1996 Jul 19;39(15):2971-9. doi: 10.1021/jm950907l. J Med Chem. 1996. PMID: 8709131

9

Technology use in long-term care during the COVID-19 pandemic: A qualitative study of paid employees' experiences in Western Canada.

Chew HJ, Freeman S, Jackson P, Hemingway D, Klassen-Ross T, Martin-Khan M, Banner D. Chew HJ, et al. Among authors: freeman s. Digit Health. 2024 Dec 19;10:20552076241303195. doi: 10.1177/20552076241303195. eCollection 2024 Jan-Dec. Digit Health. 2024. PMID: 39711747 Free PMC article.

10

Sweet's syndrome associated with FLT3 inhibition.

Seervai RNH, Munoz EP, Freeman SC, Swords RI, White KP, Keller JJ. Seervai RNH, et al. Among authors: freeman sc. JAAD Case Rep. 2024 Sep 30;54:89-92. doi: 10.1016/j.jdcr.2024.09.013. eCollection 2024 Dec. JAAD Case Rep. 2024. PMID: 39687070 Free PMC article. No abstract available.

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