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Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
Levová K, Moserová M, Kotrbová V, Sulc M, Henderson CJ, Wolf CR, Phillips DH, Frei E, Schmeiser HH, Mares J, Arlt VM, Stiborová M. Levová K, et al. Among authors: moserova m. Toxicol Sci. 2011 May;121(1):43-56. doi: 10.1093/toxsci/kfr050. Epub 2011 Feb 28. Toxicol Sci. 2011. PMID: 21362632 Free article.
Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.
Kotrbová V, Mrázová B, Moserová M, Martínek V, Hodek P, Hudeček J, Frei E, Stiborová M. Kotrbová V, et al. Among authors: moserova m. Biochem Pharmacol. 2011 Sep 15;82(6):669-80. doi: 10.1016/j.bcp.2011.06.003. Epub 2011 Jun 13. Biochem Pharmacol. 2011. PMID: 21683692
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.
Stiborová M, Indra R, Moserová M, Cerná V, Rupertová M, Martínek V, Eckschlager T, Kizek R, Frei E. Stiborová M, et al. Among authors: moserova m. Chem Res Toxicol. 2012 May 21;25(5):1075-85. doi: 10.1021/tx3000335. Epub 2012 Mar 15. Chem Res Toxicol. 2012. PMID: 22390216
Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.
Arlt VM, Poirier MC, Sykes SE, John K, Moserova M, Stiborova M, Wolf CR, Henderson CJ, Phillips DH. Arlt VM, et al. Among authors: moserova m. Toxicol Lett. 2012 Sep 3;213(2):160-6. doi: 10.1016/j.toxlet.2012.06.016. Epub 2012 Jul 1. Toxicol Lett. 2012. PMID: 22759596 Free PMC article.
30 results