Stearns RA - Search Results

1

In vitro metabolic activation of lumiracoxib in rat and human liver preparations.

Li Y, Slatter JG, Zhang Z, Li Y, Doss GA, Braun MP, Stearns RA, Dean DC, Baillie TA, Tang W. Li Y, et al. Among authors: stearns ra. Drug Metab Dispos. 2008 Feb;36(2):469-73. doi: 10.1124/dmd.107.019018. Epub 2007 Nov 12. Drug Metab Dispos. 2008. PMID: 17998295

2

Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.

Tang W, Stearns RA, Miller RR, Ngui JS, Mathvink RJ, Weber AE, Kwei GY, Strauss JR, Keohane CA, Doss GA, Chiu SH, Baillie TA. Tang W, et al. Among authors: stearns ra. Drug Metab Dispos. 2002 Jul;30(7):778-87. doi: 10.1124/dmd.30.7.778. Drug Metab Dispos. 2002. PMID: 12065436

3

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.

Chen Q, Ngui JS, Doss GA, Wang RW, Cai X, DiNinno FP, Blizzard TA, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: stearns ra. Chem Res Toxicol. 2002 Jul;15(7):907-14. doi: 10.1021/tx0200109. Chem Res Toxicol. 2002. PMID: 12119000

4

A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

Yin W, Doss GA, Stearns RA, Chaudhary AG, Hop CE, Franklin RB, Kumar S. Yin W, et al. Among authors: stearns ra. Drug Metab Dispos. 2003 Feb;31(2):215-23. doi: 10.1124/dmd.31.2.215. Drug Metab Dispos. 2003. PMID: 12527703

5

N-acetylation of the glutamate residue of intact glutathione conjugates in rats: a novel pathway for the metabolic processing of thiol adducts of xenobiotics.

Yin W, Doss GA, Stearns RA, Kumar S. Yin W, et al. Among authors: stearns ra. Drug Metab Dispos. 2004 Jan;32(1):43-8. doi: 10.1124/dmd.32.1.43. Drug Metab Dispos. 2004. PMID: 14709619

6

Identification of a hydroxylamine glucuronide metabolite of an oral hypoglycemic agent.

Miller RR, Doss GA, Stearns RA. Miller RR, et al. Among authors: stearns ra. Drug Metab Dispos. 2004 Feb;32(2):178-85. doi: 10.1124/dmd.32.2.178. Drug Metab Dispos. 2004. PMID: 14744939

7

Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes.

Xu S, Zhu B, Teffera Y, Pan DE, Caldwell CG, Doss G, Stearns RA, Evans DC, Beconi MG. Xu S, et al. Among authors: stearns ra. Drug Metab Dispos. 2005 Jan;33(1):121-30. doi: 10.1124/dmd.104.001842. Epub 2004 Oct 14. Drug Metab Dispos. 2005. PMID: 15486074

8

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.

Zhang Z, Chen Q, Li Y, Doss GA, Dean BJ, Ngui JS, Silva Elipe M, Kim S, Wu JY, Dininno F, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Zhang Z, et al. Among authors: stearns ra. Chem Res Toxicol. 2005 Apr;18(4):675-85. doi: 10.1021/tx0496789. Chem Res Toxicol. 2005. PMID: 15833027

9

Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.

Chen Q, Doss GA, Tung EC, Liu W, Tang YS, Braun MP, Didolkar V, Strauss JR, Wang RW, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: stearns ra. Drug Metab Dispos. 2006 Jan;34(1):145-51. doi: 10.1124/dmd.105.004341. Epub 2005 Oct 26. Drug Metab Dispos. 2006. PMID: 16251255

10

The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices.

Stearns RA, Miller RR, Doss GA, Chakravarty PK, Rosegay A, Gatto GJ, Chiu SH. Stearns RA, et al. Drug Metab Dispos. 1992 Mar-Apr;20(2):281-7. Drug Metab Dispos. 1992. PMID: 1352222

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