Downes CP - Search Results

1

Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.

Hale BG, Batty IH, Downes CP, Randall RE. Hale BG, et al. Among authors: downes cp. J Biol Chem. 2008 Jan 18;283(3):1372-1380. doi: 10.1074/jbc.M708862200. Epub 2007 Nov 20. J Biol Chem. 2008. PMID: 18029356 Free article.

2

Muscarinic receptors mediate phospholipase C-dependent activation of protein kinase B via Ca2+, ErbB3, and phosphoinositide 3-kinase in 1321N1 astrocytoma cells.

Tang X, Batty IH, Downes CP. Tang X, et al. Among authors: downes cp. J Biol Chem. 2002 Jan 4;277(1):338-44. doi: 10.1074/jbc.M108927200. Epub 2001 Nov 1. J Biol Chem. 2002. PMID: 11694521 Free article.

3

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.

Dixon MJ, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, Nedyalkova L, Park HW, Leslie NR, van Aalten DM, Downes CP, Batty IH. Dixon MJ, et al. Among authors: downes cp. J Biol Chem. 2012 Jun 29;287(27):22483-96. doi: 10.1074/jbc.M112.352773. Epub 2012 Apr 5. J Biol Chem. 2012. PMID: 22493426 Free PMC article.

4

A novel, rapid, and highly sensitive mass assay for phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) and its application to measure insulin-stimulated PtdIns(3,4,5)P3 production in rat skeletal muscle in vivo.

van der Kaay J, Batty IH, Cross DA, Watt PW, Downes CP. van der Kaay J, et al. Among authors: downes cp. J Biol Chem. 1997 Feb 28;272(9):5477-81. doi: 10.1074/jbc.272.9.5477. J Biol Chem. 1997. PMID: 9038150 Free article.

5

Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle.

Hajduch E, Rencurel F, Balendran A, Batty IH, Downes CP, Hundal HS. Hajduch E, et al. Among authors: downes cp. J Biol Chem. 1999 May 7;274(19):13563-8. doi: 10.1074/jbc.274.19.13563. J Biol Chem. 1999. PMID: 10224126 Free article.

6

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif.

Walker SM, Leslie NR, Perera NM, Batty IH, Downes CP. Walker SM, et al. Among authors: downes cp. Biochem J. 2004 Apr 15;379(Pt 2):301-7. doi: 10.1042/BJ20031839. Biochem J. 2004. PMID: 14711368 Free PMC article.

7

Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells.

Batty IH, Fleming IN, Downes CP. Batty IH, et al. Among authors: downes cp. Biochem J. 2004 May 1;379(Pt 3):641-51. doi: 10.1042/BJ20031700. Biochem J. 2004. PMID: 14769130 Free PMC article.

8

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1.

Fleming IN, Batty IH, Prescott AR, Gray A, Kular GS, Stewart H, Downes CP. Fleming IN, et al. Among authors: downes cp. Biochem J. 2004 Sep 15;382(Pt 3):857-65. doi: 10.1042/BJ20040916. Biochem J. 2004. PMID: 15242348 Free PMC article.

9

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2.

Batty IH, van der Kaay J, Gray A, Telfer JF, Dixon MJ, Downes CP. Batty IH, et al. Among authors: downes cp. Biochem J. 2007 Oct 15;407(2):255-66. doi: 10.1042/BJ20070558. Biochem J. 2007. PMID: 17672824 Free PMC article.

10

A screen for novel phosphoinositide 3-kinase effector proteins.

Dixon MJ, Gray A, Boisvert FM, Agacan M, Morrice NA, Gourlay R, Leslie NR, Downes CP, Batty IH. Dixon MJ, et al. Among authors: downes cp. Mol Cell Proteomics. 2011 Apr;10(4):M110.003178. doi: 10.1074/mcp.M110.003178. Epub 2011 Jan 24. Mol Cell Proteomics. 2011. PMID: 21263009 Free PMC article.

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