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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Mosyak L, Georgiadis K, Shane T, Svenson K, Hebert T, McDonagh T, Mackie S, Olland S, Lin L, Zhong X, Kriz R, Reifenberg EL, Collins-Racie LA, Corcoran C, Freeman B, Zollner R, Marvell T, Vera M, Sum PE, Lavallie ER, Stahl M, Somers W. Mosyak L, et al. Among authors: hebert t. Protein Sci. 2008 Jan;17(1):16-21. doi: 10.1110/ps.073287008. Epub 2007 Nov 27. Protein Sci. 2008. PMID: 18042673 Free PMC article.
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD. Westling J, et al. Among authors: hebert t. J Biol Chem. 2002 May 3;277(18):16059-66. doi: 10.1074/jbc.M108607200. Epub 2002 Feb 19. J Biol Chem. 2002. PMID: 11854269 Free article.
Enhanced Gαq Signaling in TSC2-deficient Cells Is Required for Their Neoplastic Behavior.
Tréfier A, Tousson-Abouelazm N, Yamani L, Ibrahim S, Joung KB, Pietrobon A, Yockell-Lelievre J, Hébert TE, Ladak RJ, Takano T, Nellist M, Namkung Y, Chatenet D, Stanford WL, Laporte SA, Kristof AS. Tréfier A, et al. Among authors: hebert te. Am J Respir Cell Mol Biol. 2024 Nov 8. doi: 10.1165/rcmb.2024-0111OC. Online ahead of print. Am J Respir Cell Mol Biol. 2024. PMID: 39514407
Torture, Livelihoods and Rehabilitation.
Hebert TL. Hebert TL. Torture. 2024;34(2):22-33. doi: 10.7146/torture.v34i2.146998. Torture. 2024. PMID: 39469954 Free article.
The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization.
Hanif SZ, Au CC, Torregroza I, Jannath SY, Fabiha T, Bhinder B, Washburn M, Devost D, Liu S, Bhardwaj P, Evans T, Anand PK, Tarran R, Palikhe S, Elemento O, Dow L, Blenis J, Hébert TE, Brown KA. Hanif SZ, et al. Among authors: hebert te. bioRxiv [Preprint]. 2024 Jul 23:2024.07.22.604482. doi: 10.1101/2024.07.22.604482. bioRxiv. 2024. PMID: 39091857 Free PMC article. Preprint.
300 results