Schaffner-Reckinger E - Search Results

1

A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.

Ghevaert C, Salsmann A, Watkins NA, Schaffner-Reckinger E, Rankin A, Garner SF, Stephens J, Smith GA, Debili N, Vainchenker W, de Groot PG, Huntington JA, Laffan M, Kieffer N, Ouwehand WH. Ghevaert C, et al. Blood. 2008 Apr 1;111(7):3407-14. doi: 10.1182/blood-2007-09-112615. Epub 2007 Dec 7. Blood. 2008. PMID: 18065693 Free article.

2

HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.

Watkins NA, Schaffner-Reckinger E, Allen DL, Howkins GJ, Brons NH, Smith GA, Metcalfe P, Murphy MF, Kieffer N, Ouwehand WH. Watkins NA, et al. Blood. 2002 Mar 1;99(5):1833-9. doi: 10.1182/blood.v99.5.1833. Blood. 2002. PMID: 11861302 Free article.

3

The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function.

Joutsi-Korhonen L, Preston S, Smethurst PA, Ijsseldijk M, Schaffner-Reckinger E, Armour KL, Watkins NA, Clark MR, de Groot PG, Farndale RW, Ouwehand WH, Williamson LM. Joutsi-Korhonen L, et al. Thromb Haemost. 2004 Apr;91(4):743-54. doi: 10.1160/TH03-07-0484. Thromb Haemost. 2004. PMID: 15045136

4

Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells.

Schaffner-Reckinger E, Salsmann A, Debili N, Bellis J, De Mey J, Vainchenker W, Ouwehand WH, Kieffer N. Schaffner-Reckinger E, et al. J Thromb Haemost. 2009 Jul;7(7):1207-17. doi: 10.1111/j.1538-7836.2009.03494.x. Epub 2009 May 22. J Thromb Haemost. 2009. PMID: 19486276 Free article.

5

A new functional role of the fibrinogen RGD motif as the molecular switch that selectively triggers integrin alphaIIbbeta3-dependent RhoA activation during cell spreading.

Salsmann A, Schaffner-Reckinger E, Kabile F, Plançon S, Kieffer N. Salsmann A, et al. J Biol Chem. 2005 Sep 30;280(39):33610-9. doi: 10.1074/jbc.M500146200. Epub 2005 Jun 13. J Biol Chem. 2005. PMID: 15955823 Free article.

6

RGD, the Rho'd to cell spreading.

Salsmann A, Schaffner-Reckinger E, Kieffer N. Salsmann A, et al. Eur J Cell Biol. 2006 Apr;85(3-4):249-54. doi: 10.1016/j.ejcb.2005.08.003. Epub 2005 Sep 13. Eur J Cell Biol. 2006. PMID: 16546569 Review.

7

The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.

Rodius S, Chaloin O, Moes M, Schaffner-Reckinger E, Landrieu I, Lippens G, Lin M, Zhang J, Kieffer N. Rodius S, et al. J Biol Chem. 2008 Aug 29;283(35):24212-23. doi: 10.1074/jbc.M709704200. Epub 2008 Jun 23. J Biol Chem. 2008. PMID: 18577523 Free PMC article.

8

Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding.

Plançon S, Morel-Kopp MC, Schaffner-Reckinger E, Chen P, Kieffer N. Plançon S, et al. Biochem J. 2001 Jul 15;357(Pt 2):529-36. doi: 10.1042/0264-6021:3570529. Biochem J. 2001. PMID: 11439104 Free PMC article.

9

Evidence from site-directed mutagenesis that the cytoplasmic domain of the beta3 subunit influences the conformational state of the alphaVbeta3 integrin ectodomain.

Schaffner-Reckinger E, Brons NH, Kieffer N. Schaffner-Reckinger E, et al. Thromb Haemost. 2001 Apr;85(4):716-23. Thromb Haemost. 2001. PMID: 11341510

10

Distinct involvement of beta3 integrin cytoplasmic domain tyrosine residues 747 and 759 in integrin-mediated cytoskeletal assembly and phosphotyrosine signaling.

Schaffner-Reckinger E, Gouon V, Melchior C, Plançon S, Kieffer N. Schaffner-Reckinger E, et al. J Biol Chem. 1998 May 15;273(20):12623-32. doi: 10.1074/jbc.273.20.12623. J Biol Chem. 1998. PMID: 9575224 Free article.

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