Wang M - Search Results

1

Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.

Hale C, Véniant M, Wang Z, Chen M, McCormick J, Cupples R, Hickman D, Min X, Sudom A, Xu H, Matsumoto G, Fotsch C, St Jean DJ Jr, Wang M. Hale C, et al. Among authors: wang z, wang m. Chem Biol Drug Des. 2008 Jan;71(1):36-44. doi: 10.1111/j.1747-0285.2007.00603.x. Epub 2007 Dec 7. Chem Biol Drug Des. 2008. PMID: 18069989

2

Time of the day for 11beta-HSD1 inhibition plays a role in improving glucose homeostasis in DIO mice.

Véniant MM, Hale C, Komorowski R, Chen MM, St Jean DJ, Fotsch C, Wang M. Véniant MM, et al. Among authors: wang m. Diabetes Obes Metab. 2009 Feb;11(2):109-17. doi: 10.1111/j.1463-1326.2008.00911.x. Epub 2008 May 12. Diabetes Obes Metab. 2009. PMID: 18479468

3

The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate.

Kim KW, Wang Z, Busby J, Tsuruda T, Chen M, Hale C, Castro VM, Svensson S, Nybo R, Xiong F, Wang M. Kim KW, et al. Among authors: wang z, wang m. Biochim Biophys Acta. 2006 Apr;1764(4):824-30. doi: 10.1016/j.bbapap.2006.02.008. Epub 2006 Mar 20. Biochim Biophys Acta. 2006. PMID: 16580270

4

2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.

Jean DJ Jr, Yuan C, Bercot EA, Cupples R, Chen M, Fretland J, Hale C, Hungate RW, Komorowski R, Veniant M, Wang M, Zhang X, Fotsch C. Jean DJ Jr, et al. Among authors: wang m. J Med Chem. 2007 Feb 8;50(3):429-32. doi: 10.1021/jm061214f. J Med Chem. 2007. PMID: 17266194

5

The selectivity of tyrosine 280 of human 11beta-hydroxysteroid dehydrogenase type 1 in inhibitor binding.

Kim KW, Wang Z, Busby J, Tsuruda T, Chen M, Hale C, Castro VM, Svensson S, Nybo R, Xiong F, Wang M. Kim KW, et al. Among authors: wang z, wang m. FEBS Lett. 2007 Mar 6;581(5):995-9. doi: 10.1016/j.febslet.2007.01.075. Epub 2007 Feb 8. FEBS Lett. 2007. PMID: 17306259 Free article.

6

The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.

Yuan C, St Jean DJ Jr, Liu Q, Cai L, Li A, Han N, Moniz G, Askew B, Hungate RW, Johansson L, Tedenborg L, Pyring D, Williams M, Hale C, Chen M, Cupples R, Zhang J, Jordan S, Bartberger MD, Sun Y, Emery M, Wang M, Fotsch C. Yuan C, et al. Among authors: wang m. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6056-61. doi: 10.1016/j.bmcl.2007.09.070. Epub 2007 Sep 25. Bioorg Med Chem Lett. 2007. PMID: 17919905

7

Development of 11beta-HSD1 inhibitors for the treatment of type 2 diabetes.

Hale C, Wang M. Hale C, et al. Among authors: wang m. Mini Rev Med Chem. 2008 Jun;8(7):702-10. doi: 10.2174/138955708784567421. Mini Rev Med Chem. 2008. PMID: 18537725 Review.

8

Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes.

Fotsch C, Wang M. Fotsch C, et al. Among authors: wang m. J Med Chem. 2008 Aug 28;51(16):4851-7. doi: 10.1021/jm800369f. Epub 2008 Jul 22. J Med Chem. 2008. PMID: 18652443 No abstract available.

9

Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.

Fotsch C, Bartberger MD, Bercot EA, Chen M, Cupples R, Emery M, Fretland J, Guram A, Hale C, Han N, Hickman D, Hungate RW, Hayashi M, Komorowski R, Liu Q, Matsumoto G, St Jean DJ Jr, Ursu S, Véniant M, Xu G, Ye Q, Yuan C, Zhang J, Zhang X, Tu H, Wang M. Fotsch C, et al. Among authors: wang m. J Med Chem. 2008 Dec 25;51(24):7953-67. doi: 10.1021/jm801073z. J Med Chem. 2008. PMID: 19053753

10

Inhibitors of 11beta-HSD1: a potential treatment for the metabolic syndrome.

St Jean DJ Jr, Wang M, Fotsch C. St Jean DJ Jr, et al. Among authors: wang m. Curr Top Med Chem. 2008;8(17):1508-23. doi: 10.2174/156802608786413528. Curr Top Med Chem. 2008. PMID: 19075762 Review.

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