Xu H - Search Results

1

Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.

Hale C, Véniant M, Wang Z, Chen M, McCormick J, Cupples R, Hickman D, Min X, Sudom A, Xu H, Matsumoto G, Fotsch C, St Jean DJ Jr, Wang M. Hale C, et al. Among authors: xu h. Chem Biol Drug Des. 2008 Jan;71(1):36-44. doi: 10.1111/j.1747-0285.2007.00603.x. Epub 2007 Dec 7. Chem Biol Drug Des. 2008. PMID: 18069989

2

Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.

Tu H, Powers JP, Liu J, Ursu S, Sudom A, Yan X, Xu H, Meininger D, Degraffenreid M, He X, Jaen JC, Sun D, Labelle M, Yamamoto H, Shan B, Walker NP, Wang Z. Tu H, et al. Among authors: xu h. Bioorg Med Chem. 2008 Oct 1;16(19):8922-31. doi: 10.1016/j.bmc.2008.08.065. Epub 2008 Aug 29. Bioorg Med Chem. 2008. PMID: 18789704

3

Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.

Min X, Yie J, Wang J, Chung BC, Huang CS, Xu H, Yang J, Deng L, Lin J, Chen Q, Abbott CM, Gundel C, Thibault SA, Meng T, Bates DL, Lloyd DJ, Véniant MM, Wang Z. Min X, et al. Among authors: xu h. MAbs. 2020 Jan-Dec;12(1):1710047. doi: 10.1080/19420862.2019.1710047. MAbs. 2020. PMID: 31905038 Free PMC article.

4

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).

Min X, Thibault ST, Porter AC, Gustin DJ, Carlson TJ, Xu H, Lindstrom M, Xu G, Uyeda C, Ma Z, Li Y, Kayser F, Walker NP, Wang Z. Min X, et al. Among authors: xu g, xu h. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. doi: 10.1073/pnas.1016167108. Epub 2011 Apr 18. Proc Natl Acad Sci U S A. 2011. PMID: 21502526 Free PMC article.

5

Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.

Wang Z, Min X, Xiao SH, Johnstone S, Romanow W, Meininger D, Xu H, Liu J, Dai J, An S, Thibault S, Walker N. Wang Z, et al. Among authors: xu h. Structure. 2013 May 7;21(5):798-809. doi: 10.1016/j.str.2013.02.025. Epub 2013 Apr 18. Structure. 2013. PMID: 23602659 Free article.

6

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

Chen X, Kopecky DJ, Mihalic J, Jeffries S, Min X, Heath J, Deignan J, Lai S, Fu Z, Guimaraes C, Shen S, Li S, Johnstone S, Thibault S, Xu H, Cardozo M, Shen W, Walker N, Kayser F, Wang Z. Chen X, et al. Among authors: xu h. J Med Chem. 2012 Apr 26;55(8):3837-51. doi: 10.1021/jm300037x. Epub 2012 Apr 18. J Med Chem. 2012. PMID: 22458568

7

T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties.

Li Y, Wang Z, Furukawa N, Escaron P, Weiszmann J, Lee G, Lindstrom M, Liu J, Liu X, Xu H, Plotnikova O, Prasad V, Walker N, Learned RM, Chen JL. Li Y, et al. Among authors: xu h. J Biol Chem. 2008 Apr 4;283(14):9168-76. doi: 10.1074/jbc.M800104200. Epub 2008 Feb 7. J Biol Chem. 2008. PMID: 18263587 Free article.

8

Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo.

Motani A, Wang Z, Conn M, Siegler K, Zhang Y, Liu Q, Johnstone S, Xu H, Thibault S, Wang Y, Fan P, Connors R, Le H, Xu G, Walker N, Shan B, Coward P. Motani A, et al. Among authors: xu g, xu h. J Biol Chem. 2009 Mar 20;284(12):7673-80. doi: 10.1074/jbc.M809654200. Epub 2009 Jan 15. J Biol Chem. 2009. PMID: 19147488 Free PMC article.

9

Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.

Wang Y, Connors R, Fan P, Wang X, Wang Z, Liu J, Kayser F, Medina JC, Johnstone S, Xu H, Thibault S, Walker N, Conn M, Zhang Y, Liu Q, Grillo MP, Motani A, Coward P, Wang Z. Wang Y, et al. Among authors: xu h. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2885-91. doi: 10.1016/j.bmcl.2014.04.089. Epub 2014 May 2. Bioorg Med Chem Lett. 2014. PMID: 24835984

10

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors.

Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T. Wang Z, et al. Among authors: xu h. Nature. 2003 May 29;423(6939):555-60. doi: 10.1038/nature01645. Nature. 2003. PMID: 12774125

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