Yang J - Search Results

1

Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.

Gangjee A, Li W, Yang J, Kisliuk RL. Gangjee A, et al. Among authors: yang j. J Med Chem. 2008 Jan 10;51(1):68-76. doi: 10.1021/jm701052u. Epub 2007 Dec 12. J Med Chem. 2008. PMID: 18072727 Free PMC article.

2

Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases.

Gangjee A, Yang J, Ihnat MA, Kamat S. Gangjee A, et al. Among authors: yang j. Bioorg Med Chem. 2003 Nov 17;11(23):5155-70. doi: 10.1016/j.bmc.2003.08.034. Bioorg Med Chem. 2003. PMID: 14604679

3

Synthesis and evaluation of a classical 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine and a 2-amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine as antifolates.

Gangjee A, Yang J, McGuire JJ, Kisliuk RL. Gangjee A, et al. Among authors: yang j. Bioorg Med Chem. 2006 Dec 15;14(24):8590-8. doi: 10.1016/j.bmc.2006.08.029. Epub 2006 Sep 20. Bioorg Med Chem. 2006. PMID: 16990006 Free PMC article.

4

Novel non-classical C9-methyl-5-substituted-2,4-diaminopyrrolo[2,3-d]pyrimidines as potential inhibitors of dihydrofolate reductase and as anti-opportunistic agents.

Gangjee A, Yang J, Queener SF. Gangjee A, et al. Among authors: yang j. Bioorg Med Chem. 2006 Dec 15;14(24):8341-51. doi: 10.1016/j.bmc.2006.09.008. Epub 2006 Sep 28. Bioorg Med Chem. 2006. PMID: 17010625 Free PMC article.

5

N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.

Gangjee A, Zaware N, Raghavan S, Yang J, Thorpe JE, Ihnat MA. Gangjee A, et al. Among authors: yang j. Bioorg Med Chem. 2012 Apr 1;20(7):2444-54. doi: 10.1016/j.bmc.2012.01.029. Epub 2012 Feb 4. Bioorg Med Chem. 2012. PMID: 22370340 Free PMC article.

6

Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.

Zaware N, Sharma H, Yang J, Devambatla RK, Queener SF, Anderson KS, Gangjee A. Zaware N, et al. Among authors: yang j. ACS Med Chem Lett. 2013 Oct 4;4(12):1148-1151. doi: 10.1021/ml400208v. ACS Med Chem Lett. 2013. PMID: 24470841 Free PMC article.

7

Design, synthesis, biological evaluation, and structure-activity relationship (SAR) discussion of dipeptidyl boronate proteasome inhibitors, part I: comprehensive understanding of the SAR of alpha-amino acid boronates.

Zhu Y, Zhao X, Zhu X, Wu G, Li Y, Ma Y, Yuan Y, Yang J, Hu Y, Ai L, Gao Q. Zhu Y, et al. Among authors: yang j. J Med Chem. 2009 Jul 23;52(14):4192-9. doi: 10.1021/jm9005093. J Med Chem. 2009. PMID: 19537716

8

Inhibition of insulin-like growth factor I receptor autophosphorylation by novel 6-5 ring-fused compounds.

Li W, Favelyukis S, Yang J, Zeng Y, Yu J, Gangjee A, Miller WT. Li W, et al. Among authors: yang j. Biochem Pharmacol. 2004 Jul 1;68(1):145-54. doi: 10.1016/j.bcp.2004.03.013. Biochem Pharmacol. 2004. PMID: 15183126

9

Design, synthesis and evaluation of novel 5-phenylpyridin-2(1H)-one derivatives as potent reversible Bruton's tyrosine kinase inhibitors.

Zhao X, Xin M, Huang W, Ren Y, Jin Q, Tang F, Jiang H, Wang Y, Yang J, Mo S, Xiang H. Zhao X, et al. Among authors: yang j. Bioorg Med Chem. 2015 Jan 15;23(2):348-64. doi: 10.1016/j.bmc.2014.11.006. Epub 2014 Nov 10. Bioorg Med Chem. 2015. PMID: 25515957

10

Synthesis, in vitro and in vivo biological evaluation, and comprehensive understanding of structure-activity relationships of dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids.

Zhu Y, Wu G, Zhu X, Ma Y, Zhao X, Li Y, Yuan Y, Yang J, Yu S, Shao F, Lei M. Zhu Y, et al. Among authors: yang j. J Med Chem. 2010 Dec 23;53(24):8619-26. doi: 10.1021/jm1009742. Epub 2010 Nov 15. J Med Chem. 2010. PMID: 21077681

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