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Page 1
Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).
Vaccaro W, Huynh T, Lloyd J, Atwal K, Finlay HJ, Levesque P, Conder ML, Jenkins-West T, Shi H, Sun L. Vaccaro W, et al. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6381-5. doi: 10.1016/j.bmcl.2008.10.099. Epub 2008 Oct 25. Bioorg Med Chem Lett. 2008. PMID: 19004630
Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.
Ahmad S, Doweyko L, Ashfaq A, Ferrara FN, Bisaha SN, Schmidt JB, DiMarco J, Conder ML, Jenkins-West T, Normandin DE, Russell AD, Smith MA, Levesque PC, Lodge NJ, Lloyd J, Stein PD, Atwal KS. Ahmad S, et al. Among authors: levesque pc. Bioorg Med Chem Lett. 2004 Jan 5;14(1):99-102. doi: 10.1016/j.bmcl.2003.10.003. Bioorg Med Chem Lett. 2004. PMID: 14684307
Pyrano-[2,3b]-pyridines as potassium channel antagonists.
Finlay HJ, Lloyd J, Nyman M, Conder ML, West T, Levesque P, Atwal K. Finlay HJ, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2714-8. doi: 10.1016/j.bmcl.2008.03.026. Epub 2008 Mar 14. Bioorg Med Chem Lett. 2008. PMID: 18374568
Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.
Finlay HJ, Jiang J, Caringal Y, Kover A, Conder ML, Xing D, Levesque P, Harper T, Hsueh MM, Atwal K, Blanar M, Wexler R, Lloyd J. Finlay HJ, et al. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1743-7. doi: 10.1016/j.bmcl.2013.01.064. Epub 2013 Jan 26. Bioorg Med Chem Lett. 2013. PMID: 23414837
Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).
Qiao JX, Wang TC, Adam LP, Chen AY, Taylor DS, Yang RZ, Zhuang S, Sleph PG, Li JP, Li D, Yin X, Chang M, Chen XQ, Shen H, Li J, Smith D, Wu DR, Leith L, Harikrishnan LS, Kamau MG, Miller MM, Bilder D, Rampulla R, Li YX, Xu C, Lawrence RM, Poss MA, Levesque P, Gordon DA, Huang CS, Finlay HJ, Wexler RR, Salvati ME. Qiao JX, et al. J Med Chem. 2015 Nov 25;58(22):9010-26. doi: 10.1021/acs.jmedchem.5b01363. Epub 2015 Nov 17. J Med Chem. 2015. PMID: 26524347
Benzopyran sulfonamides as KV1.5 potassium channel blockers.
Lloyd J, Atwal KS, Finlay HJ, Nyman M, Huynh T, Bhandaru R, Kover A, Schmidt J, Vaccaro W, Conder ML, Jenkins-West T, Levesque P. Lloyd J, et al. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3271-5. doi: 10.1016/j.bmcl.2007.04.020. Epub 2007 Apr 10. Bioorg Med Chem Lett. 2007. PMID: 17462888
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