Normandin DE - Search Results

1

Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.

Hangeland JJ, Cheney DL, Friends TJ, Swartz S, Levesque PC, Rich AJ, Sun L, Bridal TR, Adam LP, Normandin DE, Murugesan N, Ewing WR. Hangeland JJ, et al. Among authors: normandin de. Bioorg Med Chem Lett. 2008 Jan 15;18(2):474-8. doi: 10.1016/j.bmcl.2007.11.103. Epub 2007 Dec 3. Bioorg Med Chem Lett. 2008. PMID: 18160281

2

Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.

Ahmad S, Doweyko L, Ashfaq A, Ferrara FN, Bisaha SN, Schmidt JB, DiMarco J, Conder ML, Jenkins-West T, Normandin DE, Russell AD, Smith MA, Levesque PC, Lodge NJ, Lloyd J, Stein PD, Atwal KS. Ahmad S, et al. Among authors: normandin de. Bioorg Med Chem Lett. 2004 Jan 5;14(1):99-102. doi: 10.1016/j.bmcl.2003.10.003. Bioorg Med Chem Lett. 2004. PMID: 14684307

3

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Bi Y, Stoy P, Adam L, He B, Krupinski J, Normandin D, Pongrac R, Seliger L, Watson A, Macor JE. Bi Y, et al. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1577-80. doi: 10.1016/j.bmcl.2003.12.090. Bioorg Med Chem Lett. 2004. PMID: 15006407

4

The discovery of novel, potent and selective PDE5 inhibitors.

Bi Y, Stoy P, Adam L, He B, Krupinski J, Normandin D, Pongrac R, Seliger L, Watson A, Macor JE. Bi Y, et al. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2461-4. doi: 10.1016/s0960-894x(01)00466-8. Bioorg Med Chem Lett. 2001. PMID: 11549447

5

Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.

Yu G, Mason H, Wu X, Wang J, Chong S, Beyer B, Henwood A, Pongrac R, Seliger L, He B, Normandin D, Ferrer P, Zhang R, Adam L, Humphrey WG, Krupinski J, Macor JE. Yu G, et al. J Med Chem. 2003 Feb 13;46(4):457-60. doi: 10.1021/jm0256068. J Med Chem. 2003. PMID: 12570368

6

Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.

Yu G, Mason HJ, Wu X, Wang J, Chong S, Dorough G, Henwood A, Pongrac R, Seliger L, He B, Normandin D, Adam L, Krupinski J, Macor JE. Yu G, et al. J Med Chem. 2001 Mar 29;44(7):1025-7. doi: 10.1021/jm0155042. J Med Chem. 2001. PMID: 11297448 No abstract available.

7

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers.

Lloyd J, Schmidt JB, Rovnyak G, Ahmad S, Atwal KS, Bisaha SN, Doweyko LM, Stein PD, Traeger SC, Mathur A, Conder ML, DiMarco J, Harper TW, Jenkins-West T, Levesque PC, Normandin DE, Russell AD, Serafino RP, Smith MA, Lodge NJ. Lloyd J, et al. Among authors: normandin de. J Med Chem. 2001 Nov 8;44(23):3764-7. doi: 10.1021/jm015505u. J Med Chem. 2001. PMID: 11689063

8

Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors.

Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE. Rotella DP, et al. J Med Chem. 2000 Dec 28;43(26):5037-43. doi: 10.1021/jm000336j. J Med Chem. 2000. PMID: 11150175

9

Cardioselective anti-ischemic ATP-sensitive potassium channel openers. 3. Structure-activity studies on benzopyranyl cyanoguanidines: modification of the cyanoguanidine portion.

Atwal KS, Grover GJ, Ahmed SZ, Sleph PG, Dzwonczyk S, Baird AJ, Normandin DE. Atwal KS, et al. Among authors: normandin de. J Med Chem. 1995 Aug 18;38(17):3236-45. doi: 10.1021/jm00017a007. J Med Chem. 1995. PMID: 7650676

10

N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE. Rotella DP, et al. J Med Chem. 2000 Apr 6;43(7):1257-63. doi: 10.1021/jm000081+. J Med Chem. 2000. PMID: 10753463

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