Proper orientation of the nicotinamide ring of NADP is important for the precatalytic conformational change in the 6-phosphogluconate dehydrogenase reaction.
Cervellati C, Li L, Andi B, Guariento A, Dallocchio F, Cook PF.
Cervellati C, et al.
Biochemistry. 2008 Feb 19;47(7):1862-70. doi: 10.1021/bi7015684. Epub 2008 Jan 19.
Biochemistry. 2008.
PMID: 18205398
A recent study suggested sheep liver 6-phosphogluconate dehydrogenase (6PGDH) sees the oxidized and reduced cofactor differently [Cervellati, C., Dallocchio, F., Bergamini, C. M., and Cook, P. F. (2005) Biochemistry 44, 2432-2440]. ...
A recent study suggested sheep liver 6-phosphogluconate dehydrogenase (6PGDH) sees the oxidized and reduced cofactor differently [Cervell …