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78 results

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Page 1
Proline bis-amides as potent dual orexin receptor antagonists.
Bergman JM, Roecker AJ, Mercer SP, Bednar RA, Reiss DR, Ransom RW, Meacham Harrell C, Pettibone DJ, Lemaire W, Murphy KL, Li C, Prueksaritanont T, Winrow CJ, Renger JJ, Koblan KS, Hartman GD, Coleman PJ. Bergman JM, et al. Among authors: ransom rw. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1425-30. doi: 10.1016/j.bmcl.2008.01.001. Epub 2008 Jan 8. Bioorg Med Chem Lett. 2008. PMID: 18207395
Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.
Su DS, Lim JL, Markowitz MK, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Tang C, Prueksaritanont T, Freidinger RM, Bock MG. Su DS, et al. Among authors: ransom rw. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3006-9. doi: 10.1016/j.bmcl.2007.03.059. Epub 2007 Mar 21. Bioorg Med Chem Lett. 2007. PMID: 17428657
2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists.
Su DS, Lim JL, Tinney E, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Yu J, Tang C, Prueksaritanont T, Freidinger RM, Bock MG, Anthony NJ. Su DS, et al. Among authors: ransom rw. J Med Chem. 2008 Jul 10;51(13):3946-52. doi: 10.1021/jm800199h. Epub 2008 Jun 14. J Med Chem. 2008. PMID: 18553956
2,3-diaminopyridine bradykinin B1 receptor antagonists.
Kuduk SD, Ng C, Feng DM, Wai JM, Chang RS, Harrell CM, Murphy KL, Ransom RW, Reiss D, Ivarsson M, Mason G, Boyce S, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: ransom rw. J Med Chem. 2004 Dec 16;47(26):6439-42. doi: 10.1021/jm049394l. J Med Chem. 2004. PMID: 15588075
Bradykinin B1 antagonists: SAR studies in the 2,3-diaminopyridine series.
Kuduk SD, Chang RK, Ng C, Murphy KL, Ransom RW, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: ransom rw. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3925-9. doi: 10.1016/j.bmcl.2005.05.133. Bioorg Med Chem Lett. 2005. PMID: 15993596
5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists.
Kuduk SD, Di Marco CN, Chang RK, Wood MR, Kim JJ, Schirripa KM, Murphy KL, Ransom RW, Tang C, Torrent M, Ha S, Prueksaritanont T, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: ransom rw. Bioorg Med Chem Lett. 2006 May 15;16(10):2791-5. doi: 10.1016/j.bmcl.2006.01.112. Epub 2006 Mar 10. Bioorg Med Chem Lett. 2006. PMID: 16529929
Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.
Kuduk SD, Di Marco CN, Chang RK, Wood MR, Schirripa KM, Kim JJ, Wai JM, DiPardo RM, Murphy KL, Ransom RW, Harrell CM, Reiss DR, Holahan MA, Cook J, Hess JF, Sain N, Urban MO, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: ransom rw. J Med Chem. 2007 Jan 25;50(2):272-82. doi: 10.1021/jm061094b. J Med Chem. 2007. PMID: 17228869
Bradykinin B1 antagonists: biphenyl SAR studies in the cyclopropanecarboxamide series.
Kuduk SD, DiPardo RM, Chang RK, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG. Kuduk SD, et al. Among authors: ransom rw. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3608-12. doi: 10.1016/j.bmcl.2007.04.040. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17482459
Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists.
Wood MR, Schirripa KM, Kim JJ, Kuduk SD, Chang RK, Di Marco CN, DiPardo RM, Wan BL, Murphy KL, Ransom RW, Chang RS, Holahan MA, Cook JJ, Lemaire W, Mosser SD, Bednar RA, Tang C, Prueksaritanont T, Wallace AA, Mei Q, Yu J, Bohn DL, Clayton FC, Adarayn ED, Sitko GR, Leonard YM, Freidinger RM, Pettibone DJ, Bock MG. Wood MR, et al. Among authors: ransom rw. Bioorg Med Chem Lett. 2008 Jan 15;18(2):716-20. doi: 10.1016/j.bmcl.2007.11.050. Epub 2007 Nov 19. Bioorg Med Chem Lett. 2008. PMID: 18061443
78 results